| RTW INVESTMENTS, LP | 6.57M | $123.7M | $7.69M | Added$900.2K |
| RA CAPITAL MANAGEMENT, L.P. | 5.71M | $107.4M | — | New |
| Frazier Life Sciences Management, L.P. | 1.9M | $35.8M | $2.23M | Added$2.23M |
| Citadel | 1.69M | $31.8M | $1.97M | Added$1.99M |
| BAMCO INC /NY/ | 1.66M | $31.2M | $1.66M | Added$6.18M |
| ADAR1 Capital Management, LLC | 1.43M | $26.8M | $1.46M | Added$4.82M |
| Fidelity | 1.26M | $23.7M | $1.48M | Cut−$1.66M |
| BlackRock, Inc. | 865.1K | $16.3M | $743.2K | Added$5.07M |
| Rock Springs Capital Management LP | 814.7K | $15.3M | $949.5K | Added$1.01M |
| UBS Group AG | 504.2K | $9.48M | $589.9K | Cut−$22M |
| B Group, Inc. | 450.6K | $8.48M | $468K | Added$1.42M |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 393.2K | $7.02M | $66K | Added$1.73M |
| NAN FUNG TRINITY (HK) LTD | 346.5K | $6.52M | $315.9K | Added$1.75M |
| TWO SIGMA INVESTMENTS, LP | 309.7K | $5.83M | $34.5K | Added$5.31M |
| SUPERSTRING CAPITAL MANAGEMENT LP | 275.8K | $5.19M | $230.3K | Added$1.72M |
| JANE STREET GROUP, LLC | 267.9K | $5.04M | $313.5K | Cut−$1.7M |
| AMERIPRISE FINANCIAL INC | 243.6K | $4.58M | $211.9K | Added$1.39M |
| Aberdeen Group plc | 237.7K | $4.47M | — | New |
| Hennion & Walsh Asset Management, Inc. | 214.3K | $4.03M | $239.8K | Added$415.5K |
| Tidal Investments LLC | 183.7K | $3.46M | — | New |
| NEXTBio Capital Management LP | 183.4K | $3.45M | $191.1K | Added$567.3K |
| DIMENSIONAL FUND ADVISORS LP | 174.2K | $3.27M | $198.2K | Added$203.6K |
| Privium Fund Management B.V. | 132.2K | $2.49M | $154.7K | Added$154.7K |
| State Street | 118.8K | $2.23M | $139K | Cut−$171.7K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 116.6K | $2.19M | $1.24M | Added$2.19M |
| GOLDMAN SACHS GROUP INC | 110.6K | $2.08M | $129.4K | Cut−$555.9K |
| Walleye Capital LLC | 94.7K | $1.78M | $110.8K | Cut−$4.81M |
| MORGAN STANLEY | 94.4K | $1.78M | $110.5K | Cut−$3.33M |
| ALPS ADVISORS INC | 90.8K | $1.71M | $106.3K | Added$84.1K |
| Seven Fleet Capital Management LP | 77.9K | $1.46M | — | New |
| Legal & General Group Plc | 70K | $1.32M | $81.6K | Cut−$5.53M |
| BAROMETER CAPITAL MANAGEMENT INC. | 66.5K | $1.25M | — | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 65.2K | $1.23M | $66.6K | Added$223.7K |
| DCF Advisers, LLC | 63.5K | $1.19M | $74.3K | Cut−$525.5K |
| D. E. Shaw & Co., Inc. | 63.2K | $1.19M | $74K | Cut−$3.02M |
| Virtus Investment Advisers, LLC | 47.5K | $893.7K | $45K | Added$215.3K |
| XTX Topco Ltd | 47.1K | $885.4K | — | New |
| TD Asset Management Inc | 37.4K | $704.2K | $43.8K | Cut−$824.1K |
| WealthPlan Investment Management, LLC | 36.8K | $691.5K | $43K | Added$43K |
| Point72 Asset Management, L.P. | 35.1K | $660.6K | — | New |
| Hudson Bay Capital Management LP | 30K | $564.3K | $35.1K | Cut−$1.02M |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 29.8K | $561.2K | $35.2K | Cut−$266.3K |
| Headlands Technologies LLC | 28.1K | $528.7K | $18.5K | Added$249.2K |
| Invesco Ltd. | 26.6K | $499.6K | $31.1K | Cut−$40.1K |
| NORTHERN TRUST CORP | 25.7K | $483.6K | $30.1K | Cut−$1.22M |
| Legacy Wealth Asset Management, LLC | 24.9K | $468.8K | $18.6K | Added$188.3K |
| ENVESTNET ASSET MANAGEMENT INC | 24.8K | $466.1K | $29K | Cut−$2.2M |
| GEODE CAPITAL MANAGEMENT, LLC | 23.9K | $449.2K | $27.9K | Added$27.9K |
| Squarepoint Ops LLC | 19.5K | $366.1K | — | New |
| Bridgefront Capital, LLC | 14.5K | $273.3K | — | New |
| Erste Asset Management GmbH | 15.1K | $269.5K | $453 | Added$453 |
| Renaissance Technologies | 14.3K | $269K | — | New |
| BANK OF MONTREAL /CAN/ | 13.9K | $261.5K | $16.3K | Cut−$128.4K |
| Persistent Asset Partners Ltd | 12.3K | $232.1K | $14.4K | Added$14.4K |
| AXQ CAPITAL, LP | 10.7K | $201.2K | — | New |
| Vanguard Personalized Indexing Management, LLC | 10.5K | $198.3K | — | New |
| Mariner, LLC | 10K | $188.5K | — | New |
| GROUP ONE TRADING LLC | 7.72K | $145.2K | $9.03K | Cut−$190.5K |
| JPMORGAN CHASE & CO | 6.78K | $121K | $1.42K | Cut−$5.06M |
| China Universal Asset Management Co., Ltd. | 6.08K | $114.5K | $7.12K | Added$1.92K |
| Mirae Asset Global Investments Co., Ltd. | 5.46K | $102.7K | $6.39K | Cut−$1.72M |
| WELLS FARGO & COMPANY/MN | 5.42K | $102K | $6.34K | Cut−$1.54M |
| Daiwa Securities Group Inc. | 5.4K | $101.6K | $2.82K | Added$101.6K |
| BARCLAYS PLC | 3.53K | $66.4K | $1 | Added$66.4K |
| ROYAL BANK OF CANADA | 1.74K | $33K | $2.33K | Cut−$227K |
| SIMPLEX TRADING, LLC | 1.74K | $32.6K | $203 | Added$29.6K |
| Farther Finance Advisors, LLC | 957 | $19.5K | $2.58K | Cut−$3.98K |
| US BANCORP \DE\ | 1.02K | $19.2K | $1.2K | Cut−$294.2K |
| FIFTH THIRD BANCORP | 1K | $18.9K | — | New |
| CITIGROUP INC | 959 | $18K | $1.12K | Cut−$72.8K |
| GF FUND MANAGEMENT CO. LTD. | 873 | $16.4K | $898 | Added$2.87K |
| BNP PARIBAS FINANCIAL MARKETS | 753 | $14.2K | $881 | Cut−$1.43K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 628 | $11.8K | $184 | Added$9.04K |
| C WorldWide Group Holding A/S | 510K | $9.59K | $597 | Added$597 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 291.6K | $5.49K | $341 | Cut−$5.15K |
| CWM, LLC | 289 | $5.44K | $5.43K | Added$5.42K |
| Quent Capital, LLC | 230 | $4.33K | $269 | Added$269 |
| OSAIC HOLDINGS, INC. | 220 | $4.14K | $256 | Cut−$1.49K |
| ASSETMARK, INC | 208 | $3.91K | $243 | Cut−$198 |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 202 | $3.8K | $237 | Added$237 |
| EverSource Wealth Advisors, LLC | 184 | $3.46K | $213 | Cut−$122 |
| DEUTSCHE BANK AG\ | 147 | $2.77K | $172 | Cut−$40 |
| Smartleaf Asset Management LLC | 132 | $2.36K | $29 | Cut−$3.48K |
| AMERIFLEX GROUP, INC. | 62 | $1.17K | $72 | Added$72 |
| Advisory Services Network, LLC | 50 | $941 | — | New |
| Larson Financial Group LLC | 44 | $828 | $1 | Added$810 |
| SBI Securities Co., Ltd. | 40 | $752 | $46 | Added$46 |
| IFP Advisors, Inc | 33 | $621 | $39 | Cut−$1.04K |
| Cornerstone Financial Management LLC | 32 | $602 | — | New |
| Parallel Advisors, LLC | 27 | $508 | — | New |
| Bell Investment Advisors, Inc | 26 | $490 | $19 | Added$207 |
| PNC Financial Services Group, Inc. | 22 | $414 | $26 | Cut−$4.91K |
| Caitong International Asset Management Co., Ltd | 21 | $395 | $25 | Cut−$5.34K |
| Clearstead Advisors, LLC | 9 | $170 | $11 | Added$11 |
| SG Americas Securities, LLC | 5.8K | $109 | $7 | Cut−$74 |
| Blue Trust, Inc. | 5 | $94 | $6 | Added$6 |
| RHUMBLINE ADVISERS | 5 | $94 | $6 | Cut−$4.86K |
| BESSEMER GROUP INC | 54 | $1 | −$0 | Cut−$2 |