| QVT Financial LP | 4.62M | $10.6M | — | Held |
| ORBIMED ADVISORS LLC | 4.17M | $10.1M | — | Held |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3.7M | $8.95M | — | Held |
| ACUTA CAPITAL PARTNERS, LLC | 3.41M | $8.25M | — | Held |
| Avoro Capital Advisors LLC | 2.85M | $6.9M | — | Held |
| KVP Capital Advisors, LP | 2.17M | $5.24M | — | Held |
| Siren, L.L.C. | 2.08M | $5.04M | — | Held |
| Yu Fan | 2.07M | $5.01M | — | Held |
| Vanguard | 1.59M | $3.85M | — | Held |
| STEMPOINT CAPITAL LP | 1.46M | $3.53M | — | Held |
| ACORN CAPITAL ADVISORS, LLC | 1.14M | $2.76M | — | Held |
| Ally Bridge Group (NY) LLC | 817.9K | $1.98M | — | Held |
| Renaissance Technologies | 440.7K | $1.07M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 425.4K | $1.03M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 309.9K | $749.9K | — | Held |
| BlackRock, Inc. | 299K | $723.6K | — | Held |
| Eversept Partners, LP | 260.3K | $629.8K | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 215.3K | $521K | — | Held |
| State Street | 145.5K | $352.2K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 110.1K | $266.4K | — | Held |
| NORTHERN TRUST CORP | 103.5K | $250.4K | — | Held |
| Citadel | 99K | $239.5K | — | Held |
| ADAR1 Capital Management, LLC | 77.6K | $187.8K | — | Held |
| Qube Research & Technologies Ltd | 72.3K | $175.1K | — | Held |
| JANE STREET GROUP, LLC | 69.9K | $169.2K | — | Held |
| MARSHALL WACE, LLP | 68K | $164.5K | — | Held |
| TWO SIGMA ADVISERS, LP | 42.4K | $102.6K | — | Held |
| UBS Group AG | 29.8K | $72.2K | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 28.6K | $69.3K | — | Held |
| ABG Innovation Capital Partners III GP Ltd | 26.7K | $64.5K | — | Held |
| PRELUDE CAPITAL MANAGEMENT, LLC | 18.8K | $45.5K | — | Held |
| XTX Topco Ltd | 15.7K | $38K | — | Held |
| Quadrature Capital Ltd | 11.4K | $27.7K | — | Held |
| MORGAN STANLEY | 6.75K | $16.3K | $962 | Added$12.8K |
| US BANCORP \DE\ | 3.33K | $8.07K | — | Held |
| OSAIC HOLDINGS, INC. | 3.07K | $7.43K | — | Held |
| BARTLETT & CO. WEALTH MANAGEMENT LLC | 1.33K | $3.23K | — | Held |
| Torren Management, LLC | 1.25K | $3.04K | — | Held |
| BANK OF AMERICA CORP /DE/ | 411 | $995 | $24 | Added$908 |
| Russell Investments Group, Ltd. | 386 | $934 | — | Held |
| TD Waterhouse Canada Inc. | 232 | $561 | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 160 | $387 | — | Held |
| JPMORGAN CHASE & CO | 121 | $293 | — | Held |
| GROUP ONE TRADING LLC | 100 | $242 | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 24.6K | $58 | — | Held |
| SBI Securities Co., Ltd. | 19 | $46 | — | Held |
| Parallel Advisors, LLC | 8 | $19 | — | Held |
| CWM, LLC | 25 | $0 | — | Held |