| BAKER BROS. ADVISORS LP | 5.07M | $64M | $11.9M | Added$11.9M |
| 5AM Venture Management, LLC | 4.06M | $51.2M | $9.49M | Added$9.49M |
| BlackRock, Inc. | 2.36M | $29.8M | $5.02M | Added$7.69M |
| TCG Crossover Management, LLC | 2.29M | $28.9M | $4.89M | Added$7.4M |
| Merck & Co., Inc. | 1.74M | $22M | $4.07M | Added$4.07M |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.26M | $15.9M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 1.03M | $13.1M | $2.42M | Added$2.32M |
| StepStone Group LP | 761.3K | $9.61M | $1.78M | Added$1.78M |
| GEODE CAPITAL MANAGEMENT, LLC | 667.3K | $8.42M | $1.5M | Added$1.84M |
| State Street | 533.8K | $6.74M | $1.19M | Added$1.51M |
| MILLENNIUM MANAGEMENT LLC | 519.4K | $6.55M | $1.16M | Added$1.44M |
| Jones Hill Capital LP | 374K | $4.72M | — | Held |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 333.9K | $4.21M | $781.4K | Added$484.6K |
| DIMENSIONAL FUND ADVISORS LP | 324.5K | $4.09M | $637.9K | Added$1.28M |
| NORTHERN TRUST CORP | 235K | $2.97M | $529.5K | Added$639.2K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 220.5K | $2.78M | — | Held |
| Woodline Partners LP | 216K | $2.73M | $332.5K | Added$1.26M |
| Citadel | 215K | $2.71M | $503.1K | Cut−$296.1K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 214.8K | $2.71M | $502.5K | Added$435.5K |
| GOLDMAN SACHS GROUP INC | 212.8K | $2.69M | $480.1K | Added$576.1K |
| Lynx1 Capital Management LP | 211.7K | $2.67M | $121K | Added$2.14M |
| Longaeva Partners L.P. | 205K | $2.59M | — | New |
| Renaissance Technologies | 202.1K | $2.55M | $472.9K | Cut−$46.8K |
| BNP PARIBAS FINANCIAL MARKETS | 181.1K | $2.29M | $423.5K | Added$425.7K |
| MORGAN STANLEY | 176.1K | $2.22M | $412.1K | Cut−$452.7K |
| Nuveen, LLC | 175.6K | $2.22M | $132K | Added$1.64M |
| Nantahala Capital Management, LLC | 159.3K | $2.01M | — | New |
| VANGUARD FIDUCIARY TRUST CO | 156.9K | $1.98M | — | Held |
| XTX Topco Ltd | 129.6K | $1.64M | $275.3K | Added$425.4K |
| ROYCE & ASSOCIATES LP | 120.8K | $1.53M | $282.8K | Cut−$1.02M |
| MOORE CAPITAL MANAGEMENT, LP | 105K | $1.33M | $245.7K | Added$245.7K |
| ACUTA CAPITAL PARTNERS, LLC | 89.4K | $1.13M | — | New |
| Qube Research & Technologies Ltd | 87.5K | $1.1M | $204.6K | Cut−$705.8K |
| Trexquant Investment LP | 82.7K | $1.04M | $193.6K | Cut−$202.7K |
| Icahn Capital | 79.5K | $1M | $61.4K | Added$733.3K |
| D. E. Shaw & Co., Inc. | 79K | $997.6K | $156.5K | Added$310.1K |
| AMERICAN CENTURY COMPANIES INC | 78K | $984K | $176.2K | Added$210.1K |
| Bank of New York Mellon Corp | 76.4K | $964.5K | $178.8K | Added$148.5K |
| Quantinno Capital Management LP | 71K | $896.2K | $158.5K | Added$200.1K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 70.7K | $891.7K | $141.3K | Added$319.4K |
| AMERIPRISE FINANCIAL INC | 70.3K | $886.9K | $164.5K | Added$14.2K |
| MARSHALL WACE, LLP | 53.8K | $678.5K | $48.3K | Added$466.1K |
| TD Asset Management Inc | 53.6K | $676.3K | $88.4K | Added$287.8K |
| Nan Fung Group Holdings Ltd | 49.1K | $619.4K | $114.9K | Added$114.9K |
| CANTOR FITZGERALD, L. P. | 47K | $593.1K | $110K | Added$7.18K |
| TWO SIGMA INVESTMENTS, LP | 44.6K | $562.9K | $104.4K | Added$56.1K |
| Invesco Ltd. | 41.9K | $529.1K | $96K | Added$107.3K |
| MARTINGALE ASSET MANAGEMENT L P | 41.8K | $527K | $86.7K | Added$146.1K |
| GREAT LAKES ADVISORS, LLC | 41.5K | $524.1K | $97.2K | Added$79.3K |
| BANK OF AMERICA CORP /DE/ | 39.2K | $494.9K | $91.8K | Cut−$183.4K |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 37.5K | $473.3K | $87.8K | Added$87.8K |
| HSBC HOLDINGS PLC | 38.1K | $471.8K | $41.5K | Added$255.5K |
| JANE STREET GROUP, LLC | 37.2K | $469.6K | $87.1K | Cut−$411K |
| RHUMBLINE ADVISERS | 35.9K | $453.5K | $84.1K | Added$81.2K |
| UBS Group AG | 32K | $403.6K | $44.5K | Added$207.9K |
| ADAR1 Capital Management, LLC | 30.5K | $384.9K | — | New |
| BARCLAYS PLC | 28.7K | $361.9K | $67.1K | Cut−$328.4K |
| Brevan Howard Capital Management LP | 26.3K | $332.5K | $61.7K | Cut−$160.6K |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 25K | $315.5K | $58.5K | Cut−$95.7K |
| DEUTSCHE BANK AG\ | 24.7K | $311.4K | $48.7K | Added$97.4K |
| Creative Planning | 22.2K | $280.5K | $51.7K | Added$53.5K |
| Shay Capital LLC | 21.5K | $271.9K | — | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 20.3K | $256.4K | $35.9K | Added$98.5K |
| ALLIANCEBERNSTEIN L.P. | 24.3K | $250K | $0 | Held |
| Allspring Global Investments Holdings, LLC | 19.5K | $245.6K | $45K | Added$69.8K |
| Vanguard Global Advisers, LLC | 18.4K | $232.2K | — | Held |
| MetLife Investment Management, LLC | 17.8K | $224.7K | $41.7K | Added$41.7K |
| CANADA PENSION PLAN INVESTMENT BOARD | 17.7K | $223.4K | $41.4K | Cut−$39.8K |
| Quadrature Capital Ltd | 17.5K | $221.3K | $41K | Added$12.5K |
| Fidelity | 16.9K | $213.8K | $39.4K | Added$40.9K |
| Dynamic Technology Lab Private Ltd | 16.5K | $207.9K | $38.6K | Cut−$52.1K |
| JPMORGAN CHASE & CO | 14.8K | $174.7K | $22.1K | Cut−$552.7K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13.6K | $171.3K | $31K | Added$35.2K |
| ExodusPoint Capital Management, LP | 12.1K | $152.3K | $28.2K | Cut−$232.5K |
| Inscription Capital, LLC | 11.8K | $149.4K | $27.7K | Added$27.7K |
| Russell Investments Group, Ltd. | 11.6K | $146.8K | $27.1K | Added$27.9K |
| FRANKLIN RESOURCES INC | 11.1K | $140.1K | — | New |
| IHT Wealth Management, LLC | 11.1K | $140.1K | $26K | Added$26K |
| WELLS FARGO & COMPANY/MN | 11K | $139K | $25.8K | Cut−$191.7K |
| Police & Firemen's Retirement System of New Jersey | 9.47K | $119.5K | $22.2K | Added$22.2K |
| NEW YORK STATE COMMON RETIREMENT FUND | 8.88K | $112K | $20.8K | Added$20.8K |
| China Universal Asset Management Co., Ltd. | 6.79K | $85.7K | $14.6K | Added$21.7K |
| CWM, LLC | 6.79K | $85.7K | $26.7K | Added$85.6K |
| CITIGROUP INC | 4.85K | $61.2K | $9.65K | Added$18.9K |
| Versant Capital Management, Inc | 4.05K | $51.1K | $9.47K | Added$9.47K |
| Legal & General Group Plc | 2.56K | $32.3K | $5.98K | Added$5.98K |
| Ameritas Investment Partners, Inc. | 2.42K | $30.5K | $5.66K | Added$5.66K |
| Mirae Asset Global Investments Co., Ltd. | 2K | $25.2K | $4.35K | Added$6.11K |
| Tower Research Capital LLC (TRC) | 1.67K | $21.1K | $3.91K | Added$1.16K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1.54K | $19.4K | $3.6K | Added$1.41K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1.42K | $17.9K | $1.01K | Added$13.4K |
| PNC Financial Services Group, Inc. | 1.14K | $14.4K | $2.67K | Added$2.67K |
| Sterling Capital Management LLC | 943 | $11.9K | $2.21K | Cut−$4.96K |
| Arax Advisory Partners | 919 | $11.6K | $2.15K | Added$2.16K |
| GF FUND MANAGEMENT CO. LTD. | 852 | $10.8K | $1.76K | Added$3.03K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 526K | $6.64K | $765 | Added$3.27K |
| GAMMA Investing LLC | 480 | $6.06K | $222 | Added$5.08K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 435 | $5.49K | $52 | Added$5.26K |
| EverSource Wealth Advisors, LLC | 420 | $5.3K | $881 | Added$1.44K |
| ACADIAN ASSET MANAGEMENT LLC | 333.2K | $4.2K | $726 | Added$1.01K |
| Allworth Financial LP | 309 | $3.9K | — | New |
| Optiver Holding B.V. | 258 | $3.26K | $604 | Cut−$301 |
| Private Wealth Management Group, LLC | 212 | $2.68K | $496 | Added$496 |
| SIGNATUREFD, LLC | 208 | $2.63K | $391 | Added$908 |
| MassMutual Private Wealth & Trust, FSB | 186 | $2.35K | $435 | Added$435 |
| NISA INVESTMENT ADVISORS, LLC | 161 | $2.03K | $377 | Added$377 |
| Essential Partners LLC | 154 | $1.94K | $119 | Added$1.42K |
| Cornerstone Financial Management LLC | 91 | $1.15K | $213 | Added$213 |
| US BANCORP \DE\ | 70 | $883 | — | New |
| MAI Capital Management | 54 | $682 | — | New |
| True Wealth Design, LLC | 24 | $303 | $2 | Added$292 |
| Wealth Preservation Advisors, LLC | 22 | $278 | — | New |
| ROTHSCHILD INVESTMENT LLC | 20 | $252 | $4 | Added$231 |
| Farther Finance Advisors, LLC | 17 | $229 | — | New |
| HARBOR CAPITAL ADVISORS, INC. | 18.2K | $229 | — | New |
| QUADRANT CAPITAL GROUP LLC | 18 | $228 | — | New |
| OSAIC HOLDINGS, INC. | 5 | $63 | $12 | Cut−$1.94K |
| SJS Investment Consulting Inc. | 2 | $26 | — | New |
| IFP Advisors, Inc | 1 | $13 | — | New |
| ROYAL BANK OF CANADA | 25 | $0 | −$279 | Cut−$11K |