| ADAGE CAPITAL PARTNERS GP, L.L.C. | 6.31M | $23M | — | Held |
| ORBIMED ADVISORS LLC | 6.31M | $23M | — | Held |
| Redmile Group, LLC | 5.54M | $20.2M | — | Held |
| NEXTBio Capital Management LP | 3.15M | $11.5M | — | Held |
| Prosight Management, LP | 2.38M | $8.69M | — | Held |
| Vanguard | 2.38M | $8.68M | — | Held |
| CLARK ESTATES INC/NY | 1.48M | $5.39M | — | Held |
| 683 Capital Management, LLC | 1.39M | $5.07M | — | Held |
| PINNACLE ASSOCIATES LTD | 1.35M | $4.93M | — | Held |
| BANK OF AMERICA CORP /DE/ | 1.11M | $4.04M | $1.39M | Added$1.33M |
| Point72 Asset Management, L.P. | 1.07M | $3.9M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 618.3K | $2.26M | — | Held |
| Aberdeen Group plc | 531.2K | $1.94M | — | Held |
| MARSHALL WACE, LLP | 489.9K | $1.79M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 477.4K | $1.74M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 437.7K | $1.6M | — | Held |
| BlackRock, Inc. | 418.5K | $1.53M | — | Held |
| Fidelity | 392.6K | $1.43M | — | Held |
| Renaissance Technologies | 340.7K | $1.24M | — | Held |
| TD Asset Management Inc | 251.1K | $916.3K | — | Held |
| State Street | 215.4K | $786.3K | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 195.2K | $712.5K | — | Held |
| TWO SIGMA ADVISERS, LP | 170.6K | $622.7K | — | Held |
| Pathstone Holdings, LLC | 157.1K | $573.4K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 148.4K | $541.8K | — | Held |
| NORTHERN TRUST CORP | 145.4K | $530.9K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 135.1K | $486.2K | — | Held |
| GOLDMAN SACHS GROUP INC | 128.2K | $467.8K | — | Held |
| Bank of New York Mellon Corp | 110.4K | $402.9K | — | Held |
| Citadel | 68.8K | $251.3K | — | Held |
| Connor, Clark & Lunn Investment Management Ltd. | 65.7K | $239.9K | — | Held |
| Squarepoint Ops LLC | 64.8K | $236.5K | — | Held |
| JANE STREET GROUP, LLC | 54K | $197.3K | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 42.3K | $154.4K | — | Held |
| EP Wealth Advisors, LLC | 41.2K | $150.3K | — | Held |
| PIPER SANDLER & CO. | 39.5K | $144.1K | — | Held |
| Qube Research & Technologies Ltd | 38.8K | $141.5K | — | Held |
| Invesco Ltd. | 28.2K | $103K | — | Held |
| OMERS ADMINISTRATION Corp | 26.5K | $96.7K | — | Held |
| RITHOLTZ WEALTH MANAGEMENT | 26K | $94.9K | — | Held |
| XTX Topco Ltd | 24.9K | $90.8K | — | Held |
| CITIGROUP INC | 24.8K | $90.6K | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 23.2K | $84.7K | — | Held |
| Mallini Complete Financial Planning LLC | 22.6K | $82.6K | — | Held |
| CHOREO, LLC | 27.3K | $76.5K | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 20.9K | $76.2K | — | Held |
| MORGAN STANLEY | 18.1K | $66.1K | $21K | Added$26.3K |
| PRUDENTIAL FINANCIAL INC | 17.7K | $64.6K | — | Held |
| AMERICAN CENTURY COMPANIES INC | 17.3K | $63.1K | — | Held |
| Keel Point, LLC | 14.3K | $52.1K | $18K | Cut−$58.3K |
| Engineers Gate Manager LP | 13.7K | $49.9K | — | Held |
| UBS Group AG | 13.2K | $48.2K | — | Held |
| Creative Planning | 12.3K | $45K | — | Held |
| AMERIPRISE FINANCIAL INC | 11.5K | $42K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.93M | $7.03K | — | Held |
| T. Rowe Price Investment Management, Inc. | 1.35M | $4.95K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 540 | $1.97K | — | Held |
| JPMORGAN CHASE & CO | 343 | $1.25K | — | Held |
| SBI Securities Co., Ltd. | 92 | $336 | — | Held |
| LBJ Family Wealth Advisors, Ltd. | 82.2K | $300 | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 79.4K | $289 | — | Held |
| Optiver Holding B.V. | 66 | $241 | — | Held |
| STONERIDGE INVESTMENT PARTNERS LLC | 10.5K | $38 | — | Held |
| CWM, LLC | 43 | $0 | — | Held |
| ROYAL BANK OF CANADA | 64 | $0 | — | Held |