13F

Stock

Spero Therapeutics, Inc.

SPRO · held by 56 managers

Reported value

$48.8M

Holders

56

+0 new · −0 exited

Holders’ est. mark

$474

Price effect on 3 books still in the name

Largest holder

$21.4M

GSK plc

Notable conviction

Share of each notable manager’s 13F book.

Holder count by quarter

Who holds it

Notable only
InvestorSharesValueEst. markChange
GSK plc9.19M$21.4MHeld
Pfizer Inc2.36M$5.5MHeld
Vanguard2.08M$4.85MHeld
Renaissance Technologies1.28M$2.98MHeld
Alphabet Inc.890K$2.07MHeld
Anson Funds Management LP625.1K$1.46MHeld
GEODE CAPITAL MANAGEMENT, LLC529.2K$1.23MHeld
BlackRock, Inc.433.6K$1.01MHeld
Citadel397.9K$927KHeld
TWO SIGMA INVESTMENTS, LP372.6K$868.1KHeld
SUSQUEHANNA INTERNATIONAL GROUP, LLP293.7K$684.3KHeld
Informed Momentum Co LLC218.1K$508.1KHeld
TWO SIGMA ADVISERS, LP216.6K$504.7KHeld
State Street210.2K$489.7KHeld
Ionic Capital Management LLC195.9K$456.5KHeld
INTREPID FAMILY OFFICE LLC165K$384.4KHeld
JANE STREET GROUP, LLC158.3K$368.9KHeld
SEI INVESTMENTS CO132K$307.6KHeld
OMERS ADMINISTRATION Corp131.1K$305.5KHeld
NORTHERN TRUST CORP121K$281.9KHeld
Squarepoint Ops LLC119.4K$278.3KHeld
UBS Group AG116.4K$271.3KHeld
BRIDGEWAY CAPITAL MANAGEMENT, LLC114.8K$267.5KHeld
ADAR1 Capital Management, LLC113.8K$265.2KHeld
Shay Capital LLC60.3K$140.5KHeld
Point72 Asset Management, L.P.43.6K$101.5KHeld
Quadrature Capital Ltd37.8K$88.1KHeld
SIMPLEX TRADING, LLC35.7K$83.1KHeld
Capital Asset Advisory Services LLC32.5K$81.7KHeld
AXXCESS WEALTH MANAGEMENT, LLC32.5K$75.8KHeld
Three Seasons Wealth, LLC30K$69.9KHeld
DIMENSIONAL FUND ADVISORS LP29.8K$69KHeld
CHARLES SCHWAB INVESTMENT MANAGEMENT INC28.6K$66.6KHeld
Invesco Ltd.24.7K$57.6KHeld
MILLENNIUM MANAGEMENT LLC24.1K$56.2KHeld
Assenagon Asset Management S.A.18.6K$43.4KHeld
Torrey Growth & Income Advisors17K$39.7KHeld
XTX Topco Ltd15.2K$35.4KHeld
Texas Yale Capital Corp.10K$23.3KHeld
Tower Research Capital LLC (TRC)7.21K$16.8KHeld
JONES FINANCIAL COMPANIES LLLP6.48K$15.1KHeld
JPMORGAN CHASE & CO5.37K$12.5KHeld
Cullen/Frost Bankers, Inc.3K$6.99KHeld
BANK OF AMERICA CORP /DE/744$1.73K$330Added$356
MORGAN STANLEY313$729$141Cut−$80.8K
OSAIC HOLDINGS, INC.290$675Held
WELLS FARGO & COMPANY/MN200$466Held
Rockefeller Capital Management L.P.200$466Held
GSA CAPITAL PARTNERS LLP178.9K$417Held
US BANCORP \DE\151$352Held
BNP PARIBAS FINANCIAL MARKETS40$93Held
SageView Advisory Group, LLC17$40Held
CITIGROUP INC17$40Held
Farther Finance Advisors, LLC10$23Held
SBI Securities Co., Ltd.9$21Held
FNY Investment Advisers, LLC5.3K$12$3Added$3

Positions as of Q4 2025. 13F filings arrive up to 45 days after quarter-end and omit shorts. Values are quarter-end marks, as filed. Estimated mark is the price effect on shares still held — not realized P&L or investment advice.