| 5AM Venture Management, LLC | 9.68M | $7.26M | — | Held |
| Versant Venture Management, LLC | 2.01M | $1.51M | — | Held |
| BAKER BROS. ADVISORS LP | 1.45M | $1.09M | — | Held |
| Vanguard | 882.8K | $662.1K | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 478.9K | $359.1K | — | Held |
| MILLENNIUM MANAGEMENT LLC | 380.5K | $285.2K | — | Held |
| BlackRock, Inc. | 281.8K | $211.3K | — | Held |
| PLATINUM INVESTMENT MANAGEMENT LTD | 233.1K | $174.8K | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 210.2K | $157.6K | — | Held |
| Schonfeld Strategic Advisors LLC | 93.4K | $70K | — | Held |
| State Street | 75.3K | $56.5K | — | Held |
| XTX Topco Ltd | 53K | $39.8K | — | Held |
| TWO SIGMA INVESTMENTS, LP | 51.7K | $38.8K | — | Held |
| TWO SIGMA ADVISERS, LP | 41K | $30.7K | — | Held |
| JANE STREET GROUP, LLC | 24.6K | $18.5K | — | Held |
| Engineers Gate Manager LP | 23.1K | $17.3K | — | Held |
| BARCLAYS PLC | 21.3K | $15.9K | — | New |
| NORTHERN TRUST CORP | 20.1K | $15.1K | — | Held |
| GROUP ONE TRADING LLC | 17.7K | $13.3K | — | Held |
| R Squared Ltd | 14.8K | $11.1K | — | Held |
| UBS Group AG | 13.3K | $9.96K | — | Held |
| CAPITAL ADVISORS INC/OK | 10K | $7.5K | — | Held |
| SIMPLEX TRADING, LLC | 6.33K | $4.75K | — | Held |
| MORGAN STANLEY | 4.27K | $3.2K | −$13.6K | Cut−$16.3K |
| FEDERATED HERMES, INC. | 1.16K | $868 | — | Held |
| Fidelity | 748 | $561 | — | Held |
| BANK OF AMERICA CORP /DE/ | 586 | $438 | −$449 | Cut−$116 |
| BNP PARIBAS FINANCIAL MARKETS | 510 | $382 | — | Held |
| NATIONAL BANK OF CANADA /FI/ | 400 | $295 | — | Held |
| Fortitude Family Office, LLC | 385 | $289 | — | Held |
| JPMORGAN CHASE & CO | 66 | $49 | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 52 | $39 | — | Held |
| Federation des caisses Desjardins du Quebec | 51 | $38 | — | Held |
| Rockefeller Capital Management L.P. | 39 | $29 | — | Held |
| HRT FINANCIAL LP | 27.3K | $20 | — | Held |
| TD Waterhouse Canada Inc. | 25 | $18 | — | Held |
| GSA CAPITAL PARTNERS LLP | 22.9K | $17 | — | Held |
| Optiver Holding B.V. | 20 | $15 | — | Held |
| Newbridge Financial Services Group, Inc. | 18 | $13 | — | Held |
| Dynamic Wealth Strategies, LLC | 8 | $6 | — | Held |
| CoreCap Advisors, LLC | 8 | $6 | — | Held |
| MCGUIRE CAPITAL ADVISORS INC | 2 | $2 | — | Held |
| Plante Moran Financial Advisors, LLC | 3 | $2 | — | Held |
| TUCKER ASSET MANAGEMENT LLC | 1 | $1 | — | New |
| WELLS FARGO & COMPANY/MN | 1 | $1 | — | Held |
| OSAIC HOLDINGS, INC. | 2 | $1 | — | Held |
| PFS Partners, LLC | 1 | $1 | — | Held |
| HARBOUR INVESTMENTS, INC. | 1 | $1 | — | Held |
| IFP Advisors, Inc | 1 | $1 | −$3 | Cut−$3 |
| ROYAL BANK OF CANADA | 124 | $0 | — | Held |