| Bain Capital Life Sciences Investors, LLC | 8.43M | $19.1M | −$5.31M | Cut−$5.31M |
| ABG-WTT Global Life Science Capital Partners GP Ltd | 1.85M | $4.2M | −$1.16M | Cut−$1.16M |
| VANGUARD CAPITAL MANAGEMENT LLC | 982.5K | $2.23M | — | Held |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 883.9K | $2.01M | −$39.3K | Added$1.83M |
| Advent International, L.P. | 552.4K | $1.25M | −$348K | Cut−$421.7K |
| Evernest Financial Advisors, LLC | 432.5K | $1.02M | −$173.7K | Added$552K |
| SEI INVESTMENTS CO | 284.8K | $646.5K | −$59K | Added$375K |
| MILLENNIUM MANAGEMENT LLC | 283.3K | $643K | −$73.4K | Added$305.2K |
| Legato Capital Management LLC | 274.9K | $624.1K | −$9.25K | Added$581.5K |
| GEODE CAPITAL MANAGEMENT, LLC | 247.2K | $561.3K | −$137K | Cut−$69.8K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 212.1K | $481.5K | −$108.5K | Cut−$18K |
| BlackRock, Inc. | 157.2K | $356.9K | −$98.7K | Cut−$97.4K |
| JANE STREET GROUP, LLC | 132.9K | $301.7K | −$66.3K | Cut−$3.63K |
| Renaissance Technologies | 126.6K | $287.4K | −$72.8K | Cut−$47.9K |
| 683 Capital Management, LLC | 120.8K | $274.2K | −$76.1K | Cut−$76.1K |
| VANGUARD FIDUCIARY TRUST CO | 109.7K | $249K | — | Held |
| State Street | 93.9K | $213.1K | −$57.6K | Cut−$52.2K |
| DIMENSIONAL FUND ADVISORS LP | 87.6K | $198.7K | −$35K | Added$36.2K |
| GOLDMAN SACHS GROUP INC | 71.9K | $163.2K | −$34.8K | Added$2.85K |
| FIFTH LANE CAPITAL, LP | 71K | $161.2K | −$11.2K | Added$109.8K |
| XTX Topco Ltd | 61.1K | $138.6K | — | New |
| NORTHERN TRUST CORP | 48.3K | $109.6K | −$25.5K | Cut−$7.82K |
| BANK OF AMERICA CORP /DE/ | 31K | $70.4K | −$8.15K | Added$32.9K |
| MORGAN STANLEY | 29.2K | $66.3K | −$18.4K | Cut−$24.7K |
| Temasek Holdings (Private) Ltd | 21.8K | $49.5K | — | New |
| BARCLAYS PLC | 21.6K | $49K | −$13.6K | Cut−$23.1K |
| Catalyst Funds Management Pty Ltd | 21.2K | $48.1K | — | New |
| Graham Capital Management, L.P. | 20K | $45.4K | — | New |
| AMERICAN CENTURY COMPANIES INC | 16.9K | $38.4K | −$10.7K | Cut−$10.7K |
| OMERS ADMINISTRATION Corp | 15.9K | $36.1K | −$10K | Cut−$34.7K |
| Qube Research & Technologies Ltd | 15.4K | $35K | −$9.71K | Cut−$61K |
| MARSHALL WACE, LLP | 15.2K | $34.6K | −$9.59K | Cut−$147.9K |
| OSAIC HOLDINGS, INC. | 14K | $31.8K | −$8.82K | Cut−$9.69K |
| BANCO BILBAO VIZCAYA ARGENTARIA, S.A. | 12.7K | $29K | — | New |
| Hudson Bay Capital Management LP | 12.5K | $28.4K | — | New |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | 12.5K | $28.4K | −$7.87K | Cut−$44.1K |
| Vanguard Global Advisers, LLC | 11.6K | $26.4K | — | Held |
| UBS Group AG | 11.3K | $25.5K | −$26 | Added$25.4K |
| BNP PARIBAS FINANCIAL MARKETS | 9.33K | $21.2K | −$5.88K | Cut−$11K |
| Larson Financial Group LLC | 5.49K | $12.5K | — | New |
| ROYAL BANK OF CANADA | 719 | $2K | — | New |
| CWM, LLC | 188 | $427 | — | New |
| JPMORGAN CHASE & CO | 109 | $242 | −$74 | Cut−$74 |
| ALGERT GLOBAL LLC | 23.2K | $53 | — | New |
| SBI Securities Co., Ltd. | 15 | $34 | −$10 | Cut−$10 |
| RESOURCES MANAGEMENT CORP /CT/ /ADV | 500 | $1 | $0 | Held |