| Merck & Co., Inc. | 14M | $111.8M | — | Held |
| LIGHTSPEED MANAGEMENT COMPANY, L.L.C. | 8.16M | $65M | — | Held |
| ARK Investment Management LLC | 7.88M | $62.7M | — | Held |
| AMERIPRISE FINANCIAL INC | 6.29M | $50M | — | Held |
| BlackRock, Inc. | 5.32M | $42.3M | — | Held |
| Vanguard | 3.25M | $25.9M | — | Held |
| Aberdeen Group plc | 3.25M | $25.9M | — | Held |
| AIGH Capital Management LLC | 2.9M | $23.1M | — | Held |
| KENNEDY CAPITAL MANAGEMENT LLC | 1.71M | $13.6M | — | Held |
| Blue Water Life Science Advisors, LP | 1.68M | $13.3M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 1.3M | $10.3M | — | Held |
| State Street | 1.05M | $8.36M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 983.2K | $7.83M | — | Held |
| PFM Health Sciences, LP | 805.8K | $6.41M | — | Held |
| NEXT CENTURY GROWTH INVESTORS LLC | 624.4K | $4.97M | — | Held |
| Howland Capital Management LLC | 547.1K | $4.36M | — | Held |
| Amova Asset Management Americas, Inc. | 518.4K | $4.13M | — | Held |
| Sumitomo Mitsui Trust Group, Inc. | 518.4K | $4.13M | — | Held |
| STATE OF MICHIGAN RETIREMENT SYSTEM | 493.8K | $3.93M | — | Held |
| Portolan Capital Management, LLC | 379.2K | $3.02M | — | Held |
| FIRST MANHATTAN CO. LLC. | 373.8K | $2.98M | — | Held |
| NORTHERN TRUST CORP | 354.9K | $2.83M | — | Held |
| GOLDMAN SACHS GROUP INC | 342.5K | $2.73M | — | Held |
| Wellington Shields Capital Management, LLC | 340K | $2.71M | — | Held |
| ORACLE INVESTMENT MANAGEMENT INC | 339.3K | $2.7M | — | Held |
| Nuveen, LLC | 308.7K | $2.46M | — | Held |
| UBS Group AG | 306.6K | $2.44M | — | Held |
| Wellington Shields & Co., LLC | 292.5K | $2.33M | — | Held |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | 290K | $2.31M | — | Held |
| TD Asset Management Inc | 271.9K | $2.16M | — | Held |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 267.7K | $2.13M | — | Held |
| PERKINS CAPITAL MANAGEMENT INC | 239K | $1.9M | — | Held |
| Bruce & Co., Inc. | 233K | $1.85M | — | Held |
| MORGAN STANLEY | 224.6K | $1.79M | $323.4K | Cut−$442.7K |
| JANE STREET GROUP, LLC | 171.2K | $1.36M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 158.2K | $1.26M | — | Held |
| D.A. DAVIDSON & CO. | 145.5K | $1.16M | — | Held |
| Williams Jones Wealth Management, LLC. | 134.1K | $1.07M | — | Held |
| LPL Financial LLC | 132.3K | $1.05M | — | Held |
| Bank of New York Mellon Corp | 123K | $978.7K | — | Held |
| BARCLAYS PLC | 120K | $954.8K | $165.3K | Added$206.3K |
| AMERICAN CENTURY COMPANIES INC | 114K | $907.4K | — | Held |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 109K | $867.3K | — | Held |
| Renaissance Technologies | 93K | $740.2K | — | Held |
| Citadel | 92.2K | $733.6K | — | Held |
| ROYAL BANK OF CANADA | 79.3K | $631K | — | Held |
| Green Alpha Advisors, LLC | 68.5K | $545.4K | — | Held |
| WELLS FARGO & COMPANY/MN | 64.3K | $511.4K | — | Held |
| RHUMBLINE ADVISERS | 64.2K | $510.9K | — | Held |
| Susquehanna Portfolio Strategies, LLC | 61.8K | $492.3K | — | Held |
| BANK OF AMERICA CORP /DE/ | 60K | $477.9K | $48.8K | Added$256.8K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 56.8K | $452.4K | — | Held |
| SEI INVESTMENTS CO | 56K | $445.8K | — | Held |
| Verition Fund Management LLC | 51.8K | $412.4K | — | Held |
| POLEN CAPITAL MANAGEMENT LLC | 50.7K | $403.6K | — | Held |
| AlphaCentric Advisors LLC | 47.8K | $380.5K | — | Held |
| Invesco Ltd. | 39.9K | $317.4K | — | Held |
| XTX Topco Ltd | 39.4K | $313.7K | — | Held |
| Pathstone Holdings, LLC | 39K | $310.6K | — | Held |
| DEUTSCHE BANK AG\ | 38.8K | $309.1K | — | Held |
| TWO SIGMA INVESTMENTS, LP | 32.5K | $258.5K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 31K | $246.5K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 28.7K | $228.5K | — | Held |
| CITIGROUP INC | 27.6K | $219.8K | — | Held |
| JPMORGAN CHASE & CO | 26.7K | $212.7K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 20.3K | $161.9K | — | Held |
| US BANCORP \DE\ | 20.1K | $159.7K | — | Held |
| MetLife Investment Management, LLC | 18.7K | $148.5K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 15.8K | $125.8K | — | Held |
| Creative Planning | 15.8K | $125.5K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15.7K | $125.3K | — | Held |
| AXQ CAPITAL, LP | 15K | $119.1K | — | Held |
| China Universal Asset Management Co., Ltd. | 14.5K | $115.2K | — | Held |
| STIFEL FINANCIAL CORP | 13.9K | $110.9K | — | Held |
| GUGGENHEIM CAPITAL LLC | 13.6K | $108.1K | — | Held |
| Focus Partners Wealth | 13.5K | $107.7K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 13.5K | $107.1K | — | Held |
| ProShare Advisors LLC | 13.1K | $104.1K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 13K | $103.3K | — | Held |
| Scientech Research LLC | 12.4K | $98.7K | — | Held |
| Brooklyn Investment Group | 12K | $95.5K | — | Held |
| RAYMOND JAMES FINANCIAL INC | 11.6K | $92.3K | — | Held |
| SIMPLEX TRADING, LLC | 10.9K | $86.9K | — | Held |
| T. Rowe Price Investment Management, Inc. | 10.8M | $85.8K | — | Held |
| HSBC HOLDINGS PLC | 10.5K | $84.1K | — | Held |
| DRW Securities, LLC | 10.5K | $83.4K | — | Held |
| Icahn Capital | 10.2K | $81.5K | — | Held |
| OSAIC HOLDINGS, INC. | 6.5K | $51.7K | — | Held |
| AlphaQuest LLC | 5.01K | $39.9K | — | Held |
| Legal & General Group Plc | 4.57K | $36.4K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 4.32K | $34.3K | — | Held |
| Ameritas Investment Partners, Inc. | 4.24K | $33.7K | — | Held |
| Russell Investments Group, Ltd. | 4.18K | $33.3K | — | Held |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 3.9K | $31K | — | Held |
| Caitong International Asset Management Co., Ltd | 3.42K | $27.2K | — | Held |
| Fidelity | 3.39K | $27K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3.09K | $24.6K | — | Held |
| Sterling Capital Management LLC | 2.89K | $23K | — | Held |
| Farther Finance Advisors, LLC | 2.49K | $19.8K | — | Held |
| Berbice Capital Management LLC | 320 | $18.9K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.74K | $13.9K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.45M | $11.5K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1.26K | $10.1K | — | Held |
| PNC Financial Services Group, Inc. | 1.06K | $8.45K | — | Held |
| MCF Advisors LLC | 800 | $6.37K | — | Held |
| Tower Research Capital LLC (TRC) | 777 | $6.18K | — | Held |
| Ancora Advisors LLC | 690 | $5.49K | — | Held |
| Physician Wealth Advisors, Inc. | 437 | $3.48K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 289 | $2.3K | — | Held |
| Sound Income Strategies, LLC | 200 | $1.98K | — | Held |
| SBI Securities Co., Ltd. | 187 | $1.49K | — | Held |
| GAMMA Investing LLC | 172 | $1.37K | — | Held |
| EverSource Wealth Advisors, LLC | 165 | $1.31K | — | Held |
| Keating Financial Advisory Services, Inc. | 100 | $796 | — | Held |
| MAI Capital Management | 100 | $796 | — | Held |
| HRT FINANCIAL LP | 97.8K | $778 | — | Held |
| Allworth Financial LP | 77 | $613 | $14 | Added$547 |
| SIGNATUREFD, LLC | 57 | $454 | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 47 | $374 | — | Held |
| SG Americas Securities, LLC | 44.7K | $356 | — | Held |
| Rockefeller Capital Management L.P. | 36 | $287 | — | Held |
| Janney Montgomery Scott LLC | 30K | $239 | — | Held |
| Arax Advisory Partners | 9 | $72 | — | Held |
| AMALGAMATED BANK | 1.57K | $13 | — | Held |
| Daiwa Securities Group Inc. | 200 | $2 | — | Held |
| CWM, LLC | 24 | $0 | — | Held |