| ORBIMED ADVISORS LLC | 10.9M | $31.6M | — | Held |
| BAKER BROS. ADVISORS LP | 10.1M | $29.4M | — | Held |
| Vanguard | 1.41M | $4.1M | — | Held |
| Kynam Capital Management, LP | 788.9K | $2.29M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 788.7K | $2.29M | — | Held |
| MORGAN STANLEY | 334.9K | $971.3K | $414.9K | Added$562K |
| MARSHALL WACE, LLP | 273.9K | $794.3K | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 272.9K | $791.5K | — | Held |
| Renaissance Technologies | 271.3K | $786.8K | — | Held |
| BlackRock, Inc. | 266.3K | $772.2K | — | Held |
| TWO SIGMA ADVISERS, LP | 237.3K | $688.2K | — | Held |
| TD Asset Management Inc | 160.7K | $465.9K | — | Held |
| MILLENNIUM MANAGEMENT LLC | 151K | $437.9K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 135.9K | $394.1K | — | Held |
| State Street | 127.3K | $369.1K | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 122.8K | $356K | — | Held |
| GOLDMAN SACHS GROUP INC | 117.5K | $340.7K | — | Held |
| JANE STREET GROUP, LLC | 111K | $322K | — | Held |
| OMERS ADMINISTRATION Corp | 73K | $211.7K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 70.5K | $200.4K | — | Held |
| Point72 Asset Management, L.P. | 59.2K | $171.6K | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 53.5K | $155.2K | — | Held |
| XTX Topco Ltd | 50.2K | $145.5K | — | Held |
| NORTHERN TRUST CORP | 50.1K | $145.3K | — | Held |
| Focus Partners Wealth | 50K | $145K | — | Held |
| Connor, Clark & Lunn Investment Management Ltd. | 46.1K | $133.7K | — | Held |
| Cerity Partners LLC | 33K | $95.6K | — | Held |
| Qube Research & Technologies Ltd | 21.6K | $62.5K | — | Held |
| PRUDENTIAL FINANCIAL INC | 15.5K | $45K | — | Held |
| HSBC HOLDINGS PLC | 13.7K | $39.5K | — | Held |
| BANK OF AMERICA CORP /DE/ | 9.81K | $28.4K | $12.9K | Added$15.7K |
| BARCLAYS PLC | 8.6K | $24.9K | $12.6K | Added$12.4K |
| Fidelity | 6.15K | $17.8K | — | Held |
| SBI Securities Co., Ltd. | 2.74K | $7.95K | — | Held |
| CALDWELL SUTTER CAPITAL, INC. | 2K | $5.8K | — | Held |
| UBS Group AG | 1.86K | $5.38K | — | Held |
| ROYAL BANK OF CANADA | 1.74K | $5K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 1.63K | $4.74K | — | Held |
| PNC Financial Services Group, Inc. | 1.17K | $3.4K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 756K | $2.19K | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 535.7K | $1.55K | — | Held |
| GROUP ONE TRADING LLC | 500 | $1.45K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 95 | $276 | — | Held |
| JPMORGAN CHASE & CO | 62 | $180 | — | Held |
| Optiver Holding B.V. | 20 | $58 | — | Held |
| IFP Advisors, Inc | 1 | $3 | $2 | Cut−$23 |
| CITIGROUP INC | 1 | $3 | — | Held |
| CWM, LLC | 692 | $2 | — | Held |