| ARCH Venture Management, LLC | 2.76M | $84.9M | — | Held |
| GSK plc | 1.51M | $46.6M | — | Held |
| MWG Caph Ltd | 1.01M | $31M | — | Held |
| Vanguard | 826.4K | $25.4M | — | Held |
| Foresite Capital Management IV, LLC | 800.4K | $24.6M | — | Held |
| Orland Properties Ltd | 754.7K | $23.2M | — | Held |
| Decheng Capital LLC | 692K | $21.3M | — | Held |
| Almitas Capital LLC | 577.8K | $17.8M | — | Held |
| Foresite Capital Management V, LLC | 477.1K | $14.7M | — | Held |
| venBio Partners LLC | 337.7K | $10.4M | — | Held |
| Citadel | 324.7K | $9.99M | — | Held |
| Alphabet Inc. | 293.3K | $9.03M | — | Held |
| BlackRock, Inc. | 181.8K | $5.6M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 163K | $5.02M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 151K | $4.65M | — | Held |
| HSG Holding Ltd | 152.3K | $3.94M | — | Held |
| Invesco Ltd. | 98.6K | $3.04M | — | Held |
| GOLDMAN SACHS GROUP INC | 96.7K | $2.98M | — | Held |
| MIC Capital Management UK LLP | 87K | $2.68M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 85.4K | $2.63M | — | Held |
| RBF Capital, LLC | 74.6K | $2.3M | — | Held |
| MARSHALL WACE, LLP | 73.3K | $2.26M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 58.7K | $1.81M | — | Held |
| JOHNSON & JOHNSON | 54.9K | $1.69M | $798.1K | Added$798.1K |
| State Street | 51.5K | $1.58M | — | Held |
| MORGAN STANLEY | 42.9K | $1.32M | $538.3K | Added$720.8K |
| Ikarian Capital, LLC | 41.1K | $1.26M | — | Held |
| Renaissance Technologies | 39.5K | $1.22M | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 32.1K | $988.4K | — | Held |
| NORTHERN TRUST CORP | 30.3K | $932K | — | Held |
| Susquehanna Portfolio Strategies, LLC | 20.8K | $640.2K | — | Held |
| Clarius Group, LLC | 20K | $614.3K | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 18K | $554K | — | Held |
| BARCLAYS PLC | 16K | $491.5K | $17.3K | Added$472.1K |
| TWO SIGMA INVESTMENTS, LP | 15.6K | $480.7K | — | Held |
| UBS Group AG | 13.2K | $406.4K | — | Held |
| JANE STREET GROUP, LLC | 12.4K | $381.9K | — | Held |
| Point72 Asset Management, L.P. | 11.5K | $353.4K | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 9.52K | $292.9K | — | Held |
| Qube Research & Technologies Ltd | 9.05K | $278.6K | — | Held |
| ExodusPoint Capital Management, LP | 8.51K | $262K | — | Held |
| BANK OF AMERICA CORP /DE/ | 8.04K | $247.6K | $68K | Added$171.6K |
| RAYMOND JAMES FINANCIAL INC | 7.9K | $243.2K | — | Held |
| Candriam S.C.A. | 7.62K | $234.5K | — | Held |
| BBR PARTNERS, LLC | 6.83K | $210.4K | — | Held |
| CITIGROUP INC | 4.23K | $130.3K | — | Held |
| China Universal Asset Management Co., Ltd. | 3.46K | $106.4K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 3.17K | $97.6K | — | Held |
| Fidelity | 1.83K | $56.3K | — | Held |
| JPMORGAN CHASE & CO | 1.62K | $49.7K | — | Held |
| Tower Research Capital LLC (TRC) | 1.19K | $36.8K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 1.03K | $31.7K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 1.02K | $31.6K | — | Held |
| Advisors Asset Management, Inc. | 567 | $17.5K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 416 | $12.8K | — | Held |
| WELLS FARGO & COMPANY/MN | 125 | $3.85K | — | Held |
| OSAIC HOLDINGS, INC. | 124 | $3.82K | — | Held |
| MAI Capital Management | 100 | $3.08K | — | Held |
| US BANCORP \DE\ | 58 | $1.78K | — | Held |
| Cornerstone Financial Management LLC | 46 | $1.42K | — | Held |
| SIMPLEX TRADING, LLC | 37 | $1.14K | — | Held |
| GAMMA Investing LLC | 35 | $1.08K | — | Held |
| ROYAL BANK OF CANADA | 24 | $1K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 25 | $770 | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 13.1K | $405 | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 1.66K | $51 | — | Held |
| Daiwa Securities Group Inc. | 45 | $1 | — | Held |
| CWM, LLC | 20 | $1 | — | Held |