| SAMSARA BIOCAPITAL, LLC | 12.9M | $109.3M | — | Held |
| RTW INVESTMENTS, LP | 1.3M | $11M | — | Held |
| Paradigm Biocapital Advisors LP | 700K | $5.91M | — | Held |
| Siren, L.L.C. | 435.8K | $3.68M | — | Held |
| Alyeska Investment Group, L.P. | 403.6K | $3.4M | — | Held |
| Ikarian Capital, LLC | 360K | $3.04M | — | Held |
| Vanguard | 292.8K | $2.47M | — | Held |
| Kalehua Capital Management LLC | 139.9K | $1.18M | — | Held |
| Woodline Partners LP | 100K | $844K | — | Held |
| ADAR1 Capital Management, LLC | 100K | $844K | — | Held |
| WHI TRUST Co LLC | 97.5K | $822.8K | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 92.3K | $778.7K | — | Held |
| RAYMOND JAMES FINANCIAL INC | 88.4K | $746.4K | — | Held |
| Renaissance Technologies | 87.8K | $740.6K | — | Held |
| Redmile Group, LLC | 83K | $700.1K | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 82.6K | $697.6K | — | Held |
| 683 Capital Management, LLC | 80.6K | $680.2K | — | Held |
| MARSHALL WACE, LLP | 72.9K | $615.1K | — | Held |
| Propel Bio Management, LLC | 42.1K | $354.9K | — | Held |
| Belpointe Asset Management LLC | 40K | $337.6K | — | Held |
| Fortis Capital Advisors, LLC | 40K | $337.6K | — | Held |
| BlackRock, Inc. | 38.5K | $324.6K | — | Held |
| GOLDMAN SACHS GROUP INC | 34.3K | $289.5K | — | Held |
| JANE STREET GROUP, LLC | 33.1K | $279.5K | — | Held |
| OMERS ADMINISTRATION Corp | 30K | $253.2K | — | Held |
| MORGAN STANLEY | 27.9K | $235.9K | $66.3K | Added$91.9K |
| TWO SIGMA INVESTMENTS, LP | 27.8K | $234.3K | — | Held |
| State Street | 25.4K | $214.5K | — | Held |
| Squarepoint Ops LLC | 25.4K | $214.1K | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 22.5K | $189.9K | — | Held |
| Simplify Asset Management Inc. | 20.1K | $169.4K | — | Held |
| RBF Capital, LLC | 17.4K | $146.8K | — | Held |
| NORTHERN TRUST CORP | 13.7K | $115.2K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 12.9K | $108.5K | — | Held |
| Walleye Capital LLC | 11.2K | $94.7K | — | Held |
| XTX Topco Ltd | 10.9K | $92K | — | Held |
| Keel Point, LLC | 10.2K | $86.3K | — | New |
| Connor, Clark & Lunn Investment Management Ltd. | 10.2K | $85.7K | — | Held |
| Johnson Financial Group, Inc. | 10K | $84.4K | — | Held |
| Fidelity | 7.81K | $65.9K | — | Held |
| BANK OF AMERICA CORP /DE/ | 6.7K | $56.6K | $577 | Added$55.3K |
| BARCLAYS PLC | 6.07K | $51.2K | — | New |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | 4K | $33.8K | — | Held |
| UBS Group AG | 2.69K | $22.7K | — | Held |
| ROYAL BANK OF CANADA | 113 | $1K | — | Held |
| Fortitude Family Office, LLC | 114 | $962 | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 52 | $439 | — | Held |
| JPMORGAN CHASE & CO | 50 | $422 | — | Held |
| Parallel Advisors, LLC | 49 | $414 | — | Held |
| SBI Securities Co., Ltd. | 5 | $42 | — | Held |
| CITIGROUP INC | 1 | $8 | — | Held |