| SUVRETTA CAPITAL MANAGEMENT, LLC | 8.3M | $106.9M | −$42.1M | Cut−$36.1M |
| Cormorant Asset Management, LP | 8.27M | $106.5M | −$44.5M | Cut−$44.5M |
| BlackRock, Inc. | 7.18M | $92.5M | −$36.5M | Cut−$31.5M |
| FEDERATED HERMES, INC. | 5.67M | $73.1M | −$30.5M | Cut−$36.9M |
| FRANKLIN RESOURCES INC | 5.05M | $65.1M | −$26.8M | Cut−$25.9M |
| JANUS HENDERSON GROUP PLC | 3.6M | $46.4M | −$15.8M | Cut−$7.24M |
| VANGUARD CAPITAL MANAGEMENT LLC | 3.56M | $45.9M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3.3M | $42.5M | −$17.8M | Cut−$43.3M |
| Paradigm Biocapital Advisors LP | 3.14M | $40.5M | −$16.9M | Cut−$26.9M |
| Commodore Capital LP | 2.83M | $36.4M | — | New |
| State Street | 2.1M | $27M | −$9.87M | Cut−$6.49M |
| GEODE CAPITAL MANAGEMENT, LLC | 1.98M | $25.6M | −$10.2M | Cut−$9.14M |
| Citadel | 1.91M | $24.6M | — | New |
| Aberdeen Group plc | 1.74M | $22.4M | −$8.64M | Cut−$6.93M |
| Balyasny Asset Management L.P. | 1.44M | $18.5M | −$3.2M | Added$7.67M |
| Parkman Healthcare Partners LLC | 1.35M | $17.5M | −$5.85M | Cut−$2.41M |
| EVENTIDE ASSET MANAGEMENT, LLC | 1.25M | $16.1M | — | New |
| MORGAN STANLEY | 1.1M | $14.1M | −$1.2M | Added$10M |
| Essex Woodlands Management, Inc. | 1.08M | $14M | −$5.84M | Cut−$5.84M |
| ORBIMED ADVISORS LLC | 1.07M | $13.8M | −$5.75M | Cut−$31.3M |
| 5AM Venture Management, LLC | 1.05M | $13.5M | −$5.65M | Cut−$5.65M |
| Rosalind Advisors, Inc. | 1.04M | $13.4M | −$3.71M | Added$757.2K |
| Blue Owl Capital Holdings LP | 912.6K | $11.8M | −$2.11M | Added$4.59M |
| HSBC HOLDINGS PLC | 833.5K | $10.7M | — | New |
| STEMPOINT CAPITAL LP | 810.8K | $10.5M | −$1.9M | Added$3.99M |
| Patient Square Capital LP | 795K | $10.2M | −$4.2M | Cut−$4M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 793.9K | $10.2M | — | Held |
| Artia Global Partners LP | 767.1K | $9.89M | −$4.13M | Cut−$4.13M |
| Sio Capital Management, LLC | 721.8K | $9.3M | — | New |
| GOLDMAN SACHS GROUP INC | 699.7K | $9.02M | −$3.76M | Cut−$13.8M |
| NORTHERN TRUST CORP | 676.8K | $8.72M | −$3.11M | Cut−$1.83M |
| Candriam S.C.A. | 674.4K | $8.69M | −$3.63M | Cut−$3.63M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 640.1K | $8.25M | −$3.44M | Cut−$3.6M |
| Alyeska Investment Group, L.P. | 509.4K | $6.57M | −$2.74M | Cut−$7.76M |
| VANGUARD FIDUCIARY TRUST CO | 504.5K | $6.5M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 475.2K | $6.13M | −$2.56M | Cut−$4.04M |
| ExodusPoint Capital Management, LP | 458.1K | $5.9M | −$2.46M | Cut−$4.04M |
| TWO SIGMA INVESTMENTS, LP | 430.3K | $5.55M | −$744.9K | Added$3.02M |
| AMERIPRISE FINANCIAL INC | 423.3K | $5.46M | −$1.15M | Added$1.56M |
| DIMENSIONAL FUND ADVISORS LP | 401.1K | $5.16M | −$2.16M | Cut−$2.18M |
| BANK OF AMERICA CORP /DE/ | 383.4K | $4.94M | −$2.06M | Cut−$2.66M |
| MYDA Advisors LLC | 330K | $4.25M | −$1.61M | Cut−$1.23M |
| Simplify Asset Management Inc. | 326.1K | $4.2M | −$1.75M | Cut−$2.65M |
| Bleichroeder LP | 316.5K | $4.08M | −$1.7M | Cut−$1.7M |
| Walleye Capital LLC | 300.2K | $3.87M | — | New |
| Granahan Investment Management, LLC | 297.1K | $3.83M | −$1.6M | Cut−$2.87M |
| Nuveen, LLC | 260.3K | $3.35M | −$975.2K | Added$43.4K |
| WELLINGTON MANAGEMENT GROUP LLP | 258.9K | $3.34M | −$1.01M | Cut−$100.6K |
| Rock Springs Capital Management LP | 258.7K | $3.34M | −$1.39M | Cut−$1.39M |
| Bank of New York Mellon Corp | 255.4K | $3.29M | −$1.37M | Cut−$1.4M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 245.4K | $3.16M | $3.16M | Added$3.16M |
| DEUTSCHE BANK AG\ | 239.1K | $3.08M | −$1.22M | Cut−$1.06M |
| Propel Bio Management, LLC | 215.8K | $2.79M | — | New |
| Schonfeld Strategic Advisors LLC | 207.1K | $2.67M | −$1.11M | Cut−$9.41M |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 218.6K | $2.59M | −$1.02M | Cut−$422.5K |
| Jump Financial, LLC | 198.4K | $2.56M | — | New |
| HighVista Strategies LLC | 183K | $2.36M | — | New |
| DIADEMA PARTNERS LP | 178.5K | $2.3M | — | New |
| MARSHALL WACE, LLP | 161.8K | $2.09M | — | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 149.9K | $1.93M | −$6.32K | Added$1.91M |
| Swiss National Bank | 147.4K | $1.9M | — | New |
| Susquehanna Portfolio Strategies, LLC | 139.4K | $1.8M | −$403.2K | Added$427.3K |
| PANAGORA ASSET MANAGEMENT INC | 132.2K | $1.7M | −$711.3K | Cut−$711.3K |
| Invesco Ltd. | 131.9K | $1.7M | −$709.8K | Cut−$4.49M |
| UBS Group AG | 129.5K | $1.67M | −$696.5K | Cut−$1.78M |
| Fidelity | 129.4K | $1.67M | −$103.1K | Added$1.32M |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 127.2K | $1.64M | −$672.3K | Cut−$643.2K |
| STATE OF WISCONSIN INVESTMENT BOARD | 126.7K | $1.63M | −$324.5K | Added$531.2K |
| Renaissance Technologies | 117.3K | $1.51M | −$331.4K | Added$386.6K |
| Qube Research & Technologies Ltd | 116.5K | $1.5M | — | New |
| ALLIANCEBERNSTEIN L.P. | 75.3K | $1.38M | $1 | Added$4.5K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 105.1K | $1.35M | −$25K | Added$1.27M |
| Woodline Partners LP | 100.5K | $1.29M | −$540.5K | Cut−$540.5K |
| RHUMBLINE ADVISERS | 96.7K | $1.25M | −$479.1K | Cut−$380.7K |
| E Fund Management Co., Ltd. | 94.5K | $1.22M | — | Held |
| Squarepoint Ops LLC | 80.1K | $1.03M | — | New |
| Waverly Advisors, LLC | 77.9K | $1M | −$419.2K | Cut−$421.9K |
| Russell Investments Group, Ltd. | 71.6K | $923.3K | −$32.1K | Added$814.3K |
| WOODSTOCK CORP | 68.5K | $882.5K | −$368.3K | Cut−$368.3K |
| XTX Topco Ltd | 66.6K | $859.1K | — | New |
| Persistent Asset Partners Ltd | 59K | $760.4K | −$29K | Added$662K |
| Marex Group plc | 56.3K | $725.9K | −$257K | Cut−$147K |
| TWINBEECH CAPITAL LP | 56.3K | $725.7K | — | New |
| Legal & General Group Plc | 53.1K | $684.7K | −$36.3K | Added$561.6K |
| SEI INVESTMENTS CO | 50.5K | $651K | −$155.1K | Added$124.5K |
| SILVERBACK ASSET MANAGEMENT LLC | 50K | $644.5K | — | New |
| VANGUARD ASSET MANAGEMENT, Ltd | 49.1K | $633.3K | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 47.8K | $615.8K | −$257K | Cut−$260.1K |
| Erste Asset Management GmbH | 50K | $592.5K | −$317.5K | Cut−$317.5K |
| NISA INVESTMENT ADVISORS, LLC | 44.5K | $573.2K | −$229.5K | Cut−$206.1K |
| MetLife Investment Management, LLC | 43.5K | $560.3K | −$224.9K | Cut−$203.4K |
| BNP PARIBAS FINANCIAL MARKETS | 42.5K | $548.1K | −$228.8K | Cut−$239.1K |
| SBI Okasan Asset Management Co.Ltd. | 45.7K | $541.5K | −$213.4K | Cut−$70K |
| SCOTIA CAPITAL INC. | 41.8K | $538.2K | −$169.9K | Cut−$39K |
| Legato Capital Management LLC | 39.9K | $514K | −$214.5K | Cut−$224.7K |
| China Universal Asset Management Co., Ltd. | 39.7K | $511.6K | −$158.7K | Cut−$27.2K |
| Vanguard Global Advisers, LLC | 38.9K | $501.3K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 37.7K | $485.7K | −$202.7K | Cut−$2.03M |
| JANE STREET GROUP, LLC | 36.9K | $476K | — | New |
| JPMORGAN CHASE & CO | 40.1K | $475.3K | −$238.8K | Cut−$204.1K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 36.3K | $468.2K | −$188.9K | Cut−$173.1K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 36.1K | $465K | −$122.5K | Added$48.9K |
| Creative Planning | 33.1K | $426.4K | −$168K | Cut−$144K |
| HighTower Advisors, LLC | 32.5K | $418.9K | −$174.8K | Cut−$176K |
| LEVIN CAPITAL STRATEGIES, L.P. | 31.5K | $406K | −$102.2K | Added$58.9K |
| WELLS FARGO & COMPANY/MN | 29.3K | $377.6K | −$157.6K | Cut−$1.24M |
| CITIGROUP INC | 28.9K | $372.3K | −$155.4K | Cut−$458.6K |
| Baird Financial Group, Inc. | 28.1K | $362.5K | −$94.2K | Added$42.4K |
| Cinctive Capital Management LP | 27.9K | $359.1K | — | New |
| BARCLAYS PLC | 26.2K | $337.2K | −$140.7K | Cut−$2.23M |
| State of New Jersey Common Pension Fund D | 25.5K | $328.2K | — | New |
| Cyndeo Wealth Partners, LLC | 23.4K | $302.1K | −$123.7K | Cut−$117.9K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 21.6K | $279K | — | New |
| ARIZONA STATE RETIREMENT SYSTEM | 20.5K | $263.8K | — | New |
| Vanguard Investments Australia, Ltd. | 20.4K | $263.4K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 20.1K | $258.7K | −$108K | Cut−$108K |
| NEW YORK STATE COMMON RETIREMENT FUND | 18.7K | $241.2K | −$100.7K | Cut−$100.7K |
| INTECH INVESTMENT MANAGEMENT LLC | 18.7K | $240.5K | −$100.4K | Cut−$165.1K |
| Icahn Capital | 17.7K | $228.3K | −$65.2K | Added$6.75K |
| RWC Asset Management LLP | 17.7K | $227.5K | −$92.7K | Cut−$87.3K |
| Virtus Investment Advisers, LLC | 17.1K | $219.8K | −$89.5K | Cut−$84.2K |
| PROFUND ADVISORS LLC | 16.9K | $218K | −$88.2K | Cut−$81.5K |
| KLP KAPITALFORVALTNING AS | 16.4K | $211.4K | — | New |
| GUGGENHEIM CAPITAL LLC | 16.1K | $207.6K | −$77K | Cut−$54K |
| RAYMOND JAMES FINANCIAL INC | 15.9K | $205K | −$81.8K | Cut−$72.8K |
| ProShare Advisors LLC | 14.9K | $192.6K | −$80.4K | Cut−$126.1K |
| MCF Advisors LLC | 13.4K | $173K | −$72.2K | Cut−$99.6K |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 12.3K | $158.3K | −$66.1K | Cut−$70.9K |
| Dynamic Technology Lab Private Ltd | 12.1K | $155.5K | — | New |
| PRUDENTIAL FINANCIAL INC | 11.9K | $153.6K | — | New |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 11.4K | $147.6K | −$61.6K | Cut−$61.6K |
| ROYAL BANK OF CANADA | 11.4K | $147K | −$61.6K | Cut−$201K |
| Vanguard Personalized Indexing Management, LLC | 11.1K | $143.4K | — | New |
| Pictet Asset Management Holding SA | 11K | $141.3K | — | New |
| GREAT VALLEY ADVISOR GROUP, INC. | 10.8K | $139K | — | New |
| Scientech Research LLC | 10.4K | $134.1K | — | New |
| AMERICAN CENTURY COMPANIES INC | 10.2K | $131.3K | −$54.8K | Cut−$102.5K |
| Winthrop Advisory Group LLC | 10.1K | $130.2K | — | New |
| PSP Research LLC | 10K | $128.9K | −$53.8K | Cut−$410.6K |
| Caitong International Asset Management Co., Ltd | 7.04K | $90.8K | −$903 | Added$87.7K |
| Aquatic Capital Management LLC | 6.39K | $82.3K | — | New |
| Ameritas Investment Partners, Inc. | 6.13K | $79.1K | −$33K | Cut−$33K |
| OSAIC HOLDINGS, INC. | 5.54K | $71.4K | −$29.8K | Cut−$402K |
| Mirae Asset Global Investments Co., Ltd. | 4.32K | $55.7K | −$21.6K | Cut−$17.8K |
| Tower Research Capital LLC (TRC) | 4K | $51.6K | −$5.06K | Added$34.4K |
| Sterling Capital Management LLC | 2.57K | $33.1K | −$13.8K | Cut−$46.5K |
| Rockefeller Capital Management L.P. | 2.16K | $27.9K | −$6.63K | Added$5.35K |
| JONES FINANCIAL COMPANIES LLLP | 2.11K | $26.4K | −$3.38K | Added$15.7K |
| TOTH FINANCIAL ADVISORY CORP | 2K | $25.8K | −$10.8K | Cut−$10.8K |
| GF FUND MANAGEMENT CO. LTD. | 1.86K | $24K | −$8.75K | Cut−$5.74K |
| GAMMA Investing LLC | 1.38K | $17.8K | −$6.53K | Cut−$4.35K |
| Versant Capital Management, Inc | 1.27K | $16.4K | −$6.83K | Cut−$6.83K |
| SIGNATUREFD, LLC | 1.14K | $14.7K | −$5.54K | Cut−$4.15K |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 1.04K | $13.4K | −$5.38K | Cut−$4.86K |
| Cedar Mountain Advisors, LLC | 1K | $12.9K | −$5.38K | Cut−$5.38K |
| Corient Private Wealth LLC | 127.5K | $9.54K | −$2.32M | Cut−$2.32M |
| Allworth Financial LP | 675 | $8.7K | −$3.19K | Cut−$2.13K |
| Farther Finance Advisors, LLC | 574 | $7.47K | −$2.59K | Cut−$1.53K |
| PNC Financial Services Group, Inc. | 544 | $7.01K | −$2.9K | Cut−$2.84K |
| MassMutual Private Wealth & Trust, FSB | 515 | $6.64K | −$2.18K | Cut−$761 |
| Larson Financial Group LLC | 507 | $6.54K | — | New |
| Parallel Advisors, LLC | 498 | $6.42K | −$2.68K | Cut−$2.68K |
| FIFTH THIRD BANCORP | 445 | $5.74K | — | New |
| CWM, LLC | 374 | $4.82K | $4.75K | Added$4.81K |
| Truvestments Capital LLC | 258 | $3.33K | −$1.39K | Cut−$1.39K |
| Centiva Capital, LP | 216 | $2.78K | −$1.16K | Cut−$1.37M |
| EverSource Wealth Advisors, LLC | 149 | $1.92K | −$758 | Cut−$655 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 148 | $1.91K | $101 | Added$101 |
| HUNTINGTON NATIONAL BANK | 144 | $1.86K | — | New |
| ROTHSCHILD INVESTMENT LLC | 120 | $1.55K | −$431 | Added$85 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 106.1K | $1.37K | −$498 | Cut−$323 |
| QUADRANT CAPITAL GROUP LLC | 100 | $1.29K | −$538 | Cut−$538 |
| Cornerstone Financial Management LLC | 88 | $1.13K | −$474 | Cut−$474 |
| Fortitude Family Office, LLC | 78 | $1K | −$420 | Cut−$3.29K |
| Advisory Services Network, LLC | 76 | $980 | — | New |
| US BANCORP \DE\ | 42 | $542 | −$156 | Added$12 |
| HRT FINANCIAL LP | 40K | $515 | — | New |
| Janney Montgomery Scott LLC | 30.3K | $391 | −$142 | Cut−$92 |
| MAI Capital Management | 15 | $194 | — | New |
| Essential Partners LLC | 11 | $142 | −$59 | Cut−$59 |
| SBI Securities Co., Ltd. | 7 | $90 | −$38 | Cut−$312 |
| Root Financial Partners, LLC | 5 | $64 | −$27 | Cut−$27 |
| State of Alaska, Department of Revenue | 3.58K | $46 | −$19 | Cut−$19 |
| KBC Group NV | 2.27K | $29 | — | New |
| Keating Financial Advisory Services, Inc. | 1 | $13 | — | New |
| TWIN PEAKS WEALTH ADVISORS, LLC | 1 | $13 | — | New |
| Hughes Financial Services, LLC | 1 | $13 | — | New |
| Covestor Ltd | 10 | $0 | $0 | Held |