| BVF INC/IL | 6.29M | $9.5M | — | Held |
| Vanguard | 4.04M | $6.1M | — | Held |
| BlackRock, Inc. | 3.63M | $5.48M | — | Held |
| Defilade Capital Management, L.P. | 3.29M | $4.97M | — | Held |
| Ensign Peak Advisors, Inc | 2.46M | $3.72M | — | Held |
| Zimmer Partners, LP | 2.38M | $3.6M | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 2.13M | $3.22M | — | Held |
| Blue Owl Capital Holdings LP | 1.93M | $2.91M | — | Held |
| ADAR1 Capital Management, LLC | 1.82M | $2.75M | — | Held |
| Jefferies Financial Group Inc. | 1.58M | $2.39M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 1.42M | $2.15M | — | Held |
| Catalio Capital Management, LP | 1.26M | $1.9M | — | Held |
| AWM Investment Company, Inc. | 1.1M | $1.66M | — | Held |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 1.04M | $1.57M | — | Held |
| Stonepine Capital Management, LLC | 893.1K | $1.35M | — | Held |
| Sanofi | 815K | $1.23M | — | Held |
| State Street | 773.9K | $1.17M | — | Held |
| CM Management, LLC | 650K | $981.5K | — | Held |
| 22NW, LP | 636.4K | $960.9K | — | Held |
| UBS Group AG | 593.1K | $895.6K | — | Held |
| Caligan Partners LP | 556K | $839.5K | — | Held |
| JANE STREET GROUP, LLC | 489.4K | $739K | — | Held |
| NORTHERN TRUST CORP | 429.8K | $649K | — | Held |
| Focus Partners Wealth | 317.4K | $479.3K | — | Held |
| MORGAN STANLEY | 240.5K | $363.2K | −$258.3K | Cut−$256.2K |
| GOLDMAN SACHS GROUP INC | 198.7K | $300.1K | — | Held |
| Brevan Howard Capital Management LP | 195.8K | $285.8K | — | Held |
| Renaissance Technologies | 177K | $267.3K | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 173.1K | $261.4K | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 151.6K | $228.9K | — | Held |
| Bank of New York Mellon Corp | 132.9K | $200.7K | — | Held |
| XTX Topco Ltd | 124.2K | $187.6K | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 115.7K | $174.7K | — | Held |
| Quadrature Capital Ltd | 106K | $160.1K | — | Held |
| BARCLAYS PLC | 87.5K | $132.1K | −$86.1K | Cut−$74.5K |
| Nuveen, LLC | 76.3K | $115.2K | — | Held |
| Rockefeller Capital Management L.P. | 71.7K | $108.2K | — | Held |
| Graham Capital Management, L.P. | 70.3K | $106.1K | — | Held |
| Daytona Street Capital LLC | 70.2K | $106K | — | Held |
| WELLS FARGO & COMPANY/MN | 68.9K | $104K | — | Held |
| PW Nova Financial Services LLC | 58K | $94K | — | Held |
| Icahn Capital | 60.2K | $90.9K | — | Held |
| BANK OF AMERICA CORP /DE/ | 60.1K | $90.7K | −$48.8K | Cut−$26.4K |
| Kera Capital Partners, Inc. | 39.8K | $87.5K | — | Held |
| RHUMBLINE ADVISERS | 44.6K | $67.4K | — | Held |
| Invesco Ltd. | 31.7K | $47.8K | — | Held |
| MARCO INVESTMENT MANAGEMENT LLC | 30.3K | $45.8K | — | Held |
| HOWARD FINANCIAL SERVICES, LTD. | 30K | $45.3K | — | Held |
| MARSHALL WACE, LLP | 29.5K | $44.6K | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 29.4K | $44.4K | — | Held |
| Tower Research Capital LLC (TRC) | 27.4K | $41.3K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26.8K | $40.5K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 26.8K | $40.4K | — | Held |
| Cetera Investment Advisers | 26.6K | $40.1K | — | Held |
| MILLENNIUM MANAGEMENT LLC | 23.8K | $35.9K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 22.9K | $34.5K | — | Held |
| JPMORGAN CHASE & CO | 22.4K | $33.9K | — | Held |
| TWO SIGMA SECURITIES, LLC | 19.3K | $29.2K | — | Held |
| TIAA TRUST, NATIONAL ASSOCIATION | 19K | $28.7K | — | Held |
| MERCER GLOBAL ADVISORS INC /ADV | 17.7K | $26.7K | — | Held |
| LPL Financial LLC | 17.5K | $26.4K | — | Held |
| Mariner, LLC | 12.4K | $18.7K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 11.9K | $17.9K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 11.9K | $17.9K | — | Held |
| Summit Financial, LLC | 11.5K | $17.4K | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 11.4K | $17.2K | — | Held |
| Russell Investments Group, Ltd. | 10.8K | $16.3K | — | Held |
| RAYMOND JAMES FINANCIAL INC | 10.6K | $16K | — | Held |
| ProShare Advisors LLC | 10.3K | $15.5K | — | Held |
| Forum Private Client Group LLC | 10K | $15.1K | — | Held |
| Split Rock Private Trading & Wealth Management, LLC | 10K | $15.1K | — | Held |
| Seven Fleet Capital Management LP | 6K | $9.06K | — | Held |
| Ameritas Investment Partners, Inc. | 5.98K | $9.04K | — | Held |
| Legal & General Group Plc | 5.33K | $8.05K | — | Held |
| Fidelity | 4.69K | $7.08K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 4.2K | $6.34K | — | Held |
| Sterling Capital Management LLC | 3.66K | $5.53K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3.46K | $5.22K | — | Held |
| ROYAL BANK OF CANADA | 1.59K | $3K | — | Held |
| Addison Advisors LLC | 1.3K | $1.96K | — | Held |
| CITIGROUP INC | 1.28K | $1.93K | — | Held |
| SG Americas Securities, LLC | 627.4K | $947 | — | Held |
| Clearstead Advisors, LLC | 500 | $755 | — | Held |
| OSAIC HOLDINGS, INC. | 405 | $611 | — | Held |
| EverSource Wealth Advisors, LLC | 349 | $527 | — | Held |
| Essential Partners LLC | 331 | $500 | — | New |
| SBI Securities Co., Ltd. | 63 | $95 | — | Held |
| INGALLS & SNYDER LLC | 51.8K | $78 | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 29.5K | $45 | — | Held |
| Virtu Financial LLC | 25.9K | $39 | — | Held |
| ROTHSCHILD INVESTMENT LLC | 24 | $36 | — | Held |
| PNC Financial Services Group, Inc. | 5 | $8 | — | Held |
| AMALGAMATED BANK | 1.76K | $3 | — | Held |
| CWM, LLC | 2.01K | $3 | — | Held |
| Byrne Asset Management LLC | 1 | $2 | — | Held |