| Fidelity | 3.84M | $40.6M | — | New |
| BlackRock, Inc. | 3.32M | $35.1M | — | New |
| Foresite Capital Management IV, LLC | 1.94M | $20.6M | — | New |
| Merck & Co., Inc. | 1.67M | $17.6M | — | New |
| Foresite Capital Management V, LLC | 1.32M | $14M | — | New |
| Capital World Investors | 1.14M | $12.1M | — | New |
| ALLIANCEBERNSTEIN L.P. | 1.02M | $10.8M | — | New |
| VANGUARD CAPITAL MANAGEMENT LLC | 969.4K | $10.3M | — | Held |
| EcoR1 Capital, LLC | 732.6K | $7.75M | — | New |
| BAKER BROS. ADVISORS LP | 555.6K | $5.88M | — | New |
| SOROS CAPITAL MANAGEMENT LLC | 484.7K | $5.13M | — | New |
| StepStone Group LP | 395.3K | $4.18M | — | New |
| CANADA PENSION PLAN INVESTMENT BOARD | 379K | $4.01M | — | New |
| FRANKLIN RESOURCES INC | 350K | $3.7M | — | New |
| Citadel | 310K | $3.28M | — | New |
| General Catalyst Group Management, LLC | 305.2K | $3.23M | — | New |
| GEODE CAPITAL MANAGEMENT, LLC | 273.9K | $2.9M | — | New |
| JANE STREET GROUP, LLC | 265K | $2.8M | — | New |
| Ensign Peak Advisors, Inc | 200K | $2.12M | — | New |
| WELLINGTON MANAGEMENT GROUP LLP | 185K | $1.96M | — | New |
| MILLENNIUM MANAGEMENT LLC | 175.6K | $1.86M | — | New |
| Blackstone Inc. | 168.3K | $1.78M | — | New |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 140.3K | $1.48M | — | New |
| VANGUARD FIDUCIARY TRUST CO | 132K | $1.4M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 131.1K | $1.39M | — | New |
| GOLDMAN SACHS GROUP INC | 129.3K | $1.37M | — | New |
| Comprehensive Financial Management LLC | 116.3K | $1.23M | — | New |
| LMR Partners LLP | 115K | $1.22M | — | New |
| BURKEHILL GLOBAL MANAGEMENT, LP | 115K | $1.22M | — | New |
| UBS Group AG | 99.4K | $1.05M | — | New |
| BANK OF AMERICA CORP /DE/ | 86.1K | $911.3K | — | New |
| SEVEN GRAND MANAGERS, LLC | 80K | $846.4K | — | New |
| Ghisallo Capital Management LLC | 70K | $740.6K | — | New |
| TD Asset Management Inc | 57.1K | $603.8K | — | New |
| NORTHERN TRUST CORP | 45.5K | $481.7K | — | New |
| State Street | 40.1K | $424.8K | — | New |
| Squarepoint Ops LLC | 31K | $327.7K | — | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 28.6K | $302.8K | — | New |
| XTX Topco Ltd | 26.1K | $275.7K | — | New |
| AXQ CAPITAL, LP | 15.4K | $163K | — | New |
| MORGAN STANLEY | 15.3K | $161.6K | — | New |
| TUDOR INVESTMENT CORP ET AL | 15K | $158.7K | — | New |
| Vanguard Global Advisers, LLC | 13.7K | $145.4K | — | Held |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 13.6K | $144K | — | Held |
| Hudson Bay Capital Management LP | 13.5K | $142.6K | — | New |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 10.4K | $109.8K | — | New |
| T. Rowe Price Investment Management, Inc. | 1.22M | $12.9K | — | New |
| JPMORGAN CHASE & CO | 1.3K | $12.6K | — | New |
| Tower Research Capital LLC (TRC) | 1.14K | $12.1K | — | New |
| Quantbot Technologies LP | 1.1K | $11.6K | — | New |
| PRICE T ROWE ASSOCIATES INC /MD/ | 975.8K | $10.3K | — | New |
| BARCLAYS PLC | 318 | $3.36K | — | New |