| Bain Capital Life Sciences Investors, LLC | 9.68M | $21.2M | — | Held |
| JENNISON ASSOCIATES LLC | 8.91M | $19.5M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 8.83M | $19.3M | — | Held |
| Vanguard | 4.42M | $9.68M | — | Held |
| Cormorant Asset Management, LP | 4.4M | $9.64M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 2.74M | $5.99M | — | Held |
| BlackRock, Inc. | 2.33M | $5.1M | — | Held |
| SUPERSTRING CAPITAL MANAGEMENT LP | 2.25M | $4.94M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 1.84M | $4.03M | — | Held |
| Renaissance Technologies | 1.52M | $3.33M | — | Held |
| MORGAN STANLEY | 1.34M | $2.94M | −$201.6K | Cut−$508K |
| Woodline Partners LP | 1.25M | $2.74M | — | Held |
| Schonfeld Strategic Advisors LLC | 1.2M | $2.64M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 1.09M | $2.38M | — | Held |
| MARSHALL WACE, LLP | 959.1K | $2.1M | — | Held |
| Ikarian Capital, LLC | 900K | $1.97M | — | Held |
| Opaleye Management Inc. | 900K | $1.97M | — | Held |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 756.6K | $1.63M | — | Held |
| TWO SIGMA ADVISERS, LP | 737.9K | $1.62M | — | Held |
| BURKEHILL GLOBAL MANAGEMENT, LP | 700K | $1.53M | — | Held |
| JANE STREET GROUP, LLC | 662.1K | $1.45M | — | Held |
| Ensign Peak Advisors, Inc | 550K | $1.2M | — | Held |
| KVP Capital Advisors, LP | 505.4K | $1.11M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 452K | $990K | — | Held |
| Raiffeisen Bank International AG | 450K | $967.5K | — | Held |
| GOLDMAN SACHS GROUP INC | 430.7K | $943.2K | — | Held |
| State Street | 425.5K | $931.8K | — | Held |
| UBS Group AG | 415.7K | $910.3K | — | Held |
| 683 Capital Management, LLC | 388.6K | $851K | — | Held |
| Almitas Capital LLC | 387.5K | $848.6K | — | Held |
| Qube Research & Technologies Ltd | 331.2K | $725.4K | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 243.4K | $533.1K | — | Held |
| NORTHERN TRUST CORP | 238.4K | $522.2K | — | Held |
| BARCLAYS PLC | 220.7K | $483.3K | −$463 | Added$476.1K |
| Invesco Ltd. | 189.2K | $414.3K | — | Held |
| Stonepine Capital Management, LLC | 171.1K | $374.7K | — | Held |
| XTX Topco Ltd | 155.4K | $340.3K | — | Held |
| Graham Capital Management, L.P. | 151.5K | $331.7K | — | Held |
| Squarepoint Ops LLC | 149.1K | $326.5K | — | Held |
| Hudson Bay Capital Management LP | 138.7K | $303.8K | — | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 138.3K | $302.8K | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 130.7K | $286.2K | — | Held |
| OMERS ADMINISTRATION Corp | 95.4K | $208.9K | — | Held |
| LETKO, BROSSEAU & ASSOCIATES INC | 90.5K | $198.1K | — | Held |
| TD Asset Management Inc | 88.6K | $194K | — | Held |
| CITIGROUP INC | 73.8K | $161.6K | — | Held |
| Dynamic Technology Lab Private Ltd | 66.8K | $146K | — | Held |
| Quadrature Capital Ltd | 66.4K | $145.4K | — | Held |
| AMERICAN CENTURY COMPANIES INC | 58.8K | $128.7K | — | Held |
| Point72 Asset Management, L.P. | 56.6K | $124.1K | — | Held |
| MATAURO, LLC | 55.1K | $120.7K | — | Held |
| Bank of New York Mellon Corp | 54K | $118.4K | — | Held |
| Balyasny Asset Management L.P. | 51.6K | $112.9K | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 50.8K | $111.3K | — | Held |
| Jefferies Financial Group Inc. | 45.1K | $98.8K | — | Held |
| LPL Financial LLC | 42.6K | $93.3K | — | Held |
| Lighthouse Investment Partners, LLC | 38.9K | $85.1K | — | Held |
| Citadel | 33.5K | $73.4K | — | Held |
| Tower Research Capital LLC (TRC) | 30.3K | $66.5K | — | Held |
| FRED ALGER MANAGEMENT, LLC | 28K | $61.4K | — | Held |
| MERCER GLOBAL ADVISORS INC /ADV | 26.5K | $58.1K | — | Held |
| Callan Family Office, LLC | 22.6K | $49.4K | — | Held |
| Vanguard Personalized Indexing Management, LLC | 22.4K | $49K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 20.7K | $45.2K | — | Held |
| Clear Harbor Asset Management, LLC | 19.5K | $42.7K | — | Held |
| ANTIPODES PARTNERS Ltd | 17.2K | $37.6K | — | Held |
| China Universal Asset Management Co., Ltd. | 15.7K | $34.4K | — | Held |
| CRA Financial Services, LLC | 15K | $32.9K | — | Held |
| Private Advisor Group, LLC | 14.7K | $32.2K | — | Held |
| BANK OF AMERICA CORP /DE/ | 14.4K | $31.5K | −$2.16K | Cut−$595.7K |
| Fidelity | 13K | $28.6K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13K | $28K | — | Held |
| HB Wealth Management, LLC | 10K | $21.9K | — | Held |
| T. Rowe Price Investment Management, Inc. | 9.86M | $21.6K | — | Held |
| JPMORGAN CHASE & CO | 9.8K | $21.5K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 4.68K | $10.2K | — | Held |
| PNC Financial Services Group, Inc. | 4.6K | $10.1K | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 3.5K | $7.67K | — | Held |
| WELLS FARGO & COMPANY/MN | 2K | $4.38K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.89K | $4.14K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 1.64K | $3.59K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.09M | $2.4K | — | Held |
| FLAGSHIP HARBOR ADVISORS, LLC | 1K | $2.19K | — | New |
| Russell Investments Group, Ltd. | 939 | $2.06K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 811 | $1.78K | — | Held |
| Truvestments Capital LLC | 680 | $1.49K | — | Held |
| Federation des caisses Desjardins du Quebec | 340 | $745 | — | Held |
| SBI Securities Co., Ltd. | 316 | $692 | — | Held |
| GSA CAPITAL PARTNERS LLP | 304K | $666 | — | Held |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 60 | $131 | — | Held |
| SG Americas Securities, LLC | 30.6K | $67 | — | Held |
| Optiver Holding B.V. | 24 | $53 | — | Held |
| Arax Advisory Partners | 10 | $22 | — | Held |
| ROYAL BANK OF CANADA | 123 | $0 | — | Held |
| Covestor Ltd | 34 | $0 | — | Held |