| a16z Capital Management, L.L.C. | 3.23M | $44.1M | — | Held |
| Sofinnova Investments, Inc. | 2.29M | $30.3M | — | Held |
| Cormorant Asset Management, LP | 2.04M | $27M | — | Held |
| Octagon Capital Advisors LP | 1.6M | $21.1M | — | Held |
| BlackRock, Inc. | 1.53M | $20.2M | — | Held |
| Vanguard | 1.41M | $18.7M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.05M | $13.9M | — | Held |
| ORBIMED ADVISORS LLC | 790.9K | $10.5M | — | Held |
| Sands Capital Alternatives, LLC | 786.4K | $10.4M | — | Held |
| Pivotal bioVenture Partners Investment Advisor LLC | 653.4K | $8.64M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 591.4K | $7.83M | — | Held |
| COSMIC MANAGEMENT, LLC | 501.8K | $6.64M | — | Held |
| State Street | 422.8K | $5.59M | — | Held |
| JANUS HENDERSON GROUP PLC | 409.2K | $5.41M | — | Held |
| REDPOINT MANAGEMENT, LLC | 383.3K | $5.07M | — | Held |
| D. E. Shaw & Co., Inc. | 339.9K | $4.5M | — | Held |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 334.1K | $4.42M | — | Held |
| MORGAN STANLEY | 311.7K | $4.12M | $1.68M | Added$2.78M |
| Comprehensive Financial Management LLC | 271.8K | $3.6M | — | Held |
| DIADEMA PARTNERS LP | 271.2K | $3.59M | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 243K | $3.22M | — | Held |
| Citadel | 230.5K | $3.05M | — | Held |
| Invesco Ltd. | 228.7K | $3.03M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 228.4K | $3.02M | — | Held |
| MARSHALL WACE, LLP | 222.9K | $2.95M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 219.8K | $2.91M | — | Held |
| BANK OF AMERICA CORP /DE/ | 188.7K | $2.5M | $81.7K | Added$2.43M |
| NORTHERN TRUST CORP | 167.5K | $2.22M | — | Held |
| Alessandra Capital Management, LLC | 135.7K | $1.79M | — | Held |
| ADAR1 Capital Management, LLC | 135.6K | $1.79M | — | Held |
| Walleye Capital LLC | 134.8K | $1.78M | — | Held |
| GOLDMAN SACHS GROUP INC | 126.2K | $1.67M | — | Held |
| Fidelity | 117.7K | $1.56M | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 111.8K | $1.48M | — | Held |
| AMERIPRISE FINANCIAL INC | 83K | $1.1M | — | Held |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | 80K | $1.06M | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 77.6K | $1.03M | — | Held |
| Persistent Asset Partners Ltd | 72.8K | $962.8K | — | New |
| Bank of New York Mellon Corp | 61.6K | $814.4K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 52.4K | $693.8K | — | Held |
| Icahn Capital | 51.9K | $686.9K | — | Held |
| Schonfeld Strategic Advisors LLC | 51.4K | $679.6K | — | Held |
| Squarepoint Ops LLC | 51.3K | $678.3K | — | Held |
| Stonepine Capital Management, LLC | 45K | $595.4K | — | Held |
| Jump Financial, LLC | 42.8K | $566.2K | — | Held |
| TWO SIGMA INVESTMENTS, LP | 42.2K | $557.7K | — | Held |
| Russell Investments Group, Ltd. | 41.3K | $546.5K | — | Held |
| Point72 Asset Management, L.P. | 41.2K | $544.8K | — | Held |
| Militia Capital Partners, LP | 40.3K | $533.2K | $296.2K | Added$296.2K |
| Trexquant Investment LP | 39.3K | $520.4K | — | Held |
| BARCLAYS PLC | 37.8K | $499.8K | $254K | Added$296.6K |
| XTX Topco Ltd | 36.7K | $485.9K | — | Held |
| Woodline Partners LP | 31.6K | $417.6K | — | Held |
| Nuveen, LLC | 30.8K | $407.4K | — | Held |
| UBS Group AG | 29.9K | $395.3K | — | Held |
| RHUMBLINE ADVISERS | 29.5K | $390.6K | — | Held |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 27.8K | $367.6K | — | Held |
| WELLS FARGO & COMPANY/MN | 26.6K | $351.9K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 40.4K | $312.2K | — | Held |
| STRS OHIO | 22.5K | $297.7K | — | Held |
| JPMORGAN CHASE & CO | 22K | $291.4K | — | Held |
| TWO SIGMA ADVISERS, LP | 19.5K | $258K | — | Held |
| Renaissance Technologies | 18.4K | $243.4K | — | Held |
| FOX RUN MANAGEMENT, L.L.C. | 18K | $238.6K | — | Held |
| OCCUDO QUANTITATIVE STRATEGIES LP | 17.7K | $234.6K | — | Held |
| Quadrature Capital Ltd | 16.8K | $221.9K | — | Held |
| GREAT LAKES ADVISORS, LLC | 16.2K | $214.3K | — | Held |
| DEUTSCHE BANK AG\ | 15.8K | $209K | — | Held |
| R Squared Ltd | 15K | $198.5K | — | Held |
| MetLife Investment Management, LLC | 14.4K | $191K | — | Held |
| Valor Management LLC | 13.1K | $173.4K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 12.2K | $161.3K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 11K | $145.6K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 10.2K | $135.4K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 6.58K | $87K | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 6.3K | $83.3K | — | Held |
| China Universal Asset Management Co., Ltd. | 5.84K | $77.3K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 5.1K | $67.5K | — | Held |
| SIMPLEX TRADING, LLC | 2.86K | $37.8K | — | Held |
| PNC Financial Services Group, Inc. | 2.18K | $28.9K | — | Held |
| Legal & General Group Plc | 2.15K | $28.5K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 1.74K | $23K | — | Held |
| CITIGROUP INC | 1.54K | $20.3K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1.46K | $19.3K | — | Held |
| Sterling Capital Management LLC | 1.37K | $18.1K | — | Held |
| Ameritas Investment Partners, Inc. | 1.27K | $16.8K | — | Held |
| Tower Research Capital LLC (TRC) | 1.12K | $14.9K | — | Held |
| OSAIC HOLDINGS, INC. | 883 | $11.7K | — | Held |
| Parallel Advisors, LLC | 867 | $11.5K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 704 | $9.31K | — | Held |
| ROYAL BANK OF CANADA | 640 | $9K | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 278K | $3.67K | — | Held |
| TD Waterhouse Canada Inc. | 256 | $3.38K | — | Held |
| Torren Management, LLC | 213 | $2.82K | — | Held |
| ALGERT GLOBAL LLC | 196K | $2.59K | — | Held |
| Cornerstone Planning Group LLC | 102 | $1.99K | — | Held |
| EverSource Wealth Advisors, LLC | 145 | $1.92K | — | Held |
| US BANCORP \DE\ | 122 | $1.61K | — | Held |
| Fortitude Family Office, LLC | 120 | $1.59K | — | Held |
| Cornerstone Financial Management LLC | 110 | $1.46K | — | Held |
| Essential Partners LLC | 108 | $1.43K | $419 | Added$1.09K |
| Farther Finance Advisors, LLC | 101 | $1.34K | — | Held |
| True Wealth Design, LLC | 80 | $1.06K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 57 | $754 | — | Held |
| SIGNATUREFD, LLC | 57 | $754 | — | Held |
| NATIONAL BANK OF CANADA /FI/ | 45 | $594 | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 14.8K | $196 | — | Held |
| IFP Advisors, Inc | 9 | $119 | $14 | Added$107 |
| Arax Advisory Partners | 4 | $53 | — | Held |
| CWM, LLC | 3.69K | $49 | — | Held |
| Sunbelt Securities, Inc. | 3 | $40 | — | Held |
| AMALGAMATED BANK | 745 | $10 | — | Held |
| Daiwa Securities Group Inc. | 119 | $2 | — | Held |
| Ulland Investment Advisors, LLC | 20 | $0 | — | Held |