| SUVRETTA CAPITAL MANAGEMENT, LLC | 12M | $347.4M | — | Held |
| Frazier Life Sciences Management, L.P. | 9.87M | $286.8M | — | Held |
| BlackRock, Inc. | 9.1M | $264.3M | — | Held |
| Rubric Capital Management LP | 8.27M | $240.2M | — | Held |
| Vanguard | 7.25M | $210.7M | — | Held |
| JENNISON ASSOCIATES LLC | 6.76M | $196.3M | — | Held |
| Polar Capital Holdings Plc | 5.56M | $161.4M | — | Held |
| State Street | 5.49M | $159.4M | — | Held |
| GILDER GAGNON HOWE & CO LLC | 4.45M | $129.3M | — | Held |
| MORGAN STANLEY | 4.34M | $126M | $43.6M | Added$45.4M |
| UBS Group AG | 3.24M | $94.2M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 2.75M | $80M | — | Held |
| D. E. Shaw & Co., Inc. | 2.68M | $77.9M | — | Held |
| Driehaus Capital Management LLC | 2.56M | $74.4M | — | Held |
| Ensign Peak Advisors, Inc | 1.9M | $55.2M | — | Held |
| FRANKLIN RESOURCES INC | 1.9M | $55.2M | — | Held |
| JANUS HENDERSON GROUP PLC | 1.83M | $53.2M | — | Held |
| BANK OF AMERICA CORP /DE/ | 1.67M | $48.6M | $9.06M | Added$31.8M |
| GOLDMAN SACHS GROUP INC | 1.58M | $45.8M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 1.47M | $42.6M | — | Held |
| Nuveen, LLC | 1.38M | $40.1M | — | Held |
| Pivotal bioVenture Partners Investment Advisor LLC | 1.37M | $39.7M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1.01M | $29.5M | — | Held |
| NORTHERN TRUST CORP | 955.2K | $27.7M | — | Held |
| DEUTSCHE BANK AG\ | 930.2K | $27M | — | Held |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 914K | $26.5M | — | Held |
| Perpetual Ltd | 910.6K | $26.4M | — | Held |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 900K | $26.1M | — | Held |
| FEDERATED HERMES, INC. | 891.8K | $25.9M | — | Held |
| OBERWEIS ASSET MANAGEMENT INC/ | 808.4K | $23.5M | — | Held |
| Candriam S.C.A. | 803.1K | $23.3M | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 699.8K | $20.3M | — | Held |
| Qube Research & Technologies Ltd | 661.4K | $19.2M | — | Held |
| Nearwater Capital Markets, Ltd | 615K | $17.9M | — | Held |
| Aberdeen Group plc | 586.4K | $17M | — | Held |
| FISHMAN JAY A LTD/MI | 564.6K | $16.4M | — | Held |
| MPM BIOIMPACT LLC | 531.2K | $15.4M | — | Held |
| BAMCO INC /NY/ | 504.7K | $14.7M | — | Held |
| Cormorant Asset Management, LP | 500K | $14.5M | — | Held |
| Capitolis Liquid Global Markets LLC | 500K | $14.5M | — | Held |
| Icahn Capital | 499.4K | $14.5M | — | Held |
| Squarepoint Ops LLC | 455.9K | $13.2M | — | Held |
| MARSHALL WACE, LLP | 454.2K | $13.2M | — | Held |
| Eversept Partners, LP | 434.6K | $12.6M | — | Held |
| Jump Financial, LLC | 430.9K | $12.5M | — | Held |
| Point72 Asset Management, L.P. | 425.2K | $12.3M | — | Held |
| ZEVENBERGEN CAPITAL INVESTMENTS LLC | 418K | $12.1M | — | Held |
| FIRST TRUST ADVISORS LP | 404.7K | $11.8M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 400.9K | $11.6M | — | Held |
| BARCLAYS PLC | 331.6K | $9.63M | $3.32M | Added$3.48M |
| JUPITER ASSET MANAGEMENT LTD | 326.5K | $9.48M | — | Held |
| CASTLEARK MANAGEMENT LLC | 309.4K | $8.99M | — | Held |
| Invesco Ltd. | 307.4K | $8.93M | — | Held |
| Privium Fund Management B.V. | 306K | $8.89M | — | Held |
| Bank of New York Mellon Corp | 304.4K | $8.84M | — | Held |
| WELLS FARGO & COMPANY/MN | 284.2K | $8.25M | — | Held |
| Renaissance Technologies | 274K | $7.96M | — | Held |
| MYDA Advisors LLC | 265K | $7.7M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 236.8K | $6.88M | — | Held |
| PRUDENTIAL FINANCIAL INC | 234.9K | $6.82M | — | Held |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 234.1K | $6.8M | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 231.7K | $6.73M | — | Held |
| STEMPOINT CAPITAL LP | 224.7K | $6.53M | — | Held |
| JANE STREET GROUP, LLC | 221.4K | $6.43M | — | Held |
| Informed Momentum Co LLC | 213.9K | $6.21M | — | Held |
| Swiss National Bank | 212.8K | $6.18M | — | Held |
| Patient Square Capital LP | 210K | $6.1M | — | Held |
| Fidelity | 205.4K | $5.97M | — | Held |
| NORDEA INVESTMENT MANAGEMENT AB | 201.6K | $5.85M | — | Held |
| Woodline Partners LP | 195K | $5.66M | — | Held |
| Hillsdale Investment Management Inc. | 179.4K | $5.21M | — | Held |
| Voleon Capital Management LP | 176.6K | $5.13M | — | Held |
| NORGES BANK | 174.8K | $5.08M | $2.34M | Cut−$5.55M |
| Rafferty Asset Management, LLC | 172.1K | $5M | — | Held |
| Walleye Capital LLC | 168.6K | $4.9M | — | Held |
| RHUMBLINE ADVISERS | 161.4K | $4.69M | — | Held |
| TWO SIGMA ADVISERS, LP | 156.1K | $4.53M | — | Held |
| Citadel | 155.2K | $4.51M | — | Held |
| PDT Partners, LLC | 155.1K | $4.5M | — | Held |
| RAYMOND JAMES FINANCIAL INC | 144.9K | $4.21M | — | Held |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 141.3K | $4.1M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 126K | $3.59M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 116.4K | $3.38M | — | Held |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 113.4K | $3.29M | — | Held |
| LPL Financial LLC | 111.9K | $3.25M | — | Held |
| JPMORGAN CHASE & CO | 106.5K | $3.09M | — | Held |
| TUDOR INVESTMENT CORP ET AL | 106.1K | $3.08M | $713.1K | Added$1.76M |
| SEI INVESTMENTS CO | 104.3K | $3.03M | — | Held |
| Legal & General Group Plc | 104K | $3.02M | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 102.4K | $2.97M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 99.2K | $2.88M | — | Held |
| AMERIPRISE FINANCIAL INC | 98.8K | $2.87M | — | Held |
| TD Asset Management Inc | 97.2K | $2.82M | — | Held |
| LAZARD ASSET MANAGEMENT LLC | 93.4K | $2.71M | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 88.5K | $2.56M | — | Held |
| Engineers Gate Manager LP | 86.6K | $2.52M | — | Held |
| Pictet Asset Management Holding SA | 87.7K | $2.51M | — | Held |
| Russell Investments Group, Ltd. | 78.1K | $2.27M | — | Held |
| Advisors Asset Management, Inc. | 76.6K | $2.22M | — | Held |
| XTX Topco Ltd | 74.4K | $2.16M | — | Held |
| Erste Asset Management GmbH | 73.1K | $2.09M | — | Held |
| Focus Partners Wealth | 66.6K | $1.93M | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 66.4K | $1.93M | — | Held |
| Phocas Financial Corp. | 64.5K | $1.87M | — | Held |
| PROFUND ADVISORS LLC | 64.2K | $1.86M | — | Held |
| Silverleafe Capital Partners, LLC | 63K | $1.83M | — | Held |
| Aquatic Capital Management LLC | 60.6K | $1.76M | — | Held |
| MetLife Investment Management, LLC | 60.3K | $1.75M | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 64.5K | $1.61M | — | Held |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 57.1K | $1.6M | — | Held |
| CITIGROUP INC | 55.1K | $1.6M | — | Held |
| RFG Advisory, LLC | 54.3K | $1.58M | — | Held |
| Calamos Advisors LLC | 54.2K | $1.57M | — | Held |
| Rockefeller Capital Management L.P. | 51.6K | $1.5M | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 50.6K | $1.47M | — | Held |
| AMI ASSET MANAGEMENT CORP | 49.3K | $1.43M | — | Held |
| WESBANCO BANK INC | 48.5K | $1.41M | — | Held |
| MACKENZIE FINANCIAL CORP | 49K | $1.37M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 46.2K | $1.34M | — | Held |
| Legato Capital Management LLC | 46K | $1.34M | — | Held |
| DARK FOREST CAPITAL MANAGEMENT LP | 45.8K | $1.33M | — | Held |
| Jain Global LLC | 44.8K | $1.3M | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 42.9K | $1.25M | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 39.9K | $1.16M | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 37.1K | $1.08M | — | Held |
| State of New Jersey Common Pension Fund D | 36.8K | $1.07M | — | Held |
| FOX RUN MANAGEMENT, L.L.C. | 36.7K | $1.07M | — | Held |
| GUGGENHEIM CAPITAL LLC | 32.5K | $944.1K | — | Held |
| KEYBANK NATIONAL ASSOCIATION/OH | 30.9K | $896.8K | — | Held |
| OpenArc Corporate Advisory, LLC | 30.6K | $888.7K | — | Held |
| Invst, LLC | 30.5K | $885.9K | $310.9K | Added$280.7K |
| Vontobel Holding Ltd. | 30K | $871.3K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 29.9K | $867.4K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 29.2K | $849.2K | — | Held |
| D.A. DAVIDSON & CO. | 28.7K | $834.7K | — | Held |
| DNB Asset Management AS | 27.8K | $806.9K | — | Held |
| Creative Planning | 27.2K | $788.9K | — | Held |
| Ellsworth Advisors, LLC | 29.9K | $787.8K | — | Held |
| ENVESTNET ASSET MANAGEMENT INC | 26.5K | $770.5K | — | Held |
| Mariner, LLC | 26.3K | $761.5K | — | Held |
| FARALLON CAPITAL MANAGEMENT LLC | 26K | $755K | $264.9K | Added$264.9K |
| OXFORD ASSET MANAGEMENT LLP | 25.7K | $747.1K | — | New |
| ProShare Advisors LLC | 25.5K | $741.2K | — | Held |
| Independent Advisor Alliance | 25.3K | $734.8K | — | Held |
| Cerity Partners LLC | 24.9K | $722.5K | — | Held |
| Virtus Investment Advisers, LLC | 23.5K | $683.9K | — | Held |
| KLP KAPITALFORVALTNING AS | 23.1K | $670.8K | — | Held |
| LVW Advisors, LLC | 22.2K | $644.4K | — | Held |
| STRS OHIO | 21.4K | $621.5K | — | Held |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 20.5K | $596.7K | — | Held |
| Harvest Investment Services, LLC | 20.5K | $595.3K | — | Held |
| China Universal Asset Management Co., Ltd. | 20K | $579.6K | — | Held |
| IEQ CAPITAL, LLC | 19.6K | $567.9K | — | Held |
| Elevated Financial Group LLC | 19.5K | $565.1K | — | Held |
| Quantinno Capital Management LP | 18.9K | $547.6K | — | Held |
| PSP Research LLC | 18.7K | $543.5K | — | Held |
| Trek Financial, LLC | 18.6K | $540.3K | — | Held |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 17.8K | $517.9K | — | Held |
| FORA Capital, LLC | 16.8K | $488.9K | — | Held |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 16.4K | $480.1K | — | Held |
| INDEPENDENT FINANCIAL GROUP, LLC | 16.5K | $477.9K | — | New |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 16K | $464.1K | — | Held |
| Inspire Investing, LLC | 15.8K | $459.9K | — | Held |
| GK Wealth Management LLC | 15K | $435.1K | — | Held |
| Tower Research Capital LLC (TRC) | 14.9K | $432.2K | — | Held |
| OP Asset Management Ltd | 14.9K | $431.7K | $151.5K | Added$151.3K |
| Lighthouse Investment Partners, LLC | 14.5K | $420.1K | — | Held |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 14.3K | $413.8K | — | Held |
| Mitsubishi UFJ Trust & Banking Corp | 14.2K | $412.6K | — | Held |
| PNC Financial Services Group, Inc. | 13.6K | $394.9K | — | Held |
| FRED ALGER MANAGEMENT, LLC | 13.3K | $386.3K | — | Held |
| Merit Financial Group, LLC | 13K | $378K | — | Held |
| S.E.E.D. Planning Group LLC | 13K | $377.5K | — | Held |
| COMMERCE BANK | 12.9K | $374.1K | — | Held |
| ALTFEST L J & CO INC | 12.8K | $372.6K | — | Held |
| Financiere des Professionnels - Fonds d'investissement inc. | 12.4K | $361.1K | — | Held |
| Entropy Technologies, LP | 12.1K | $352.7K | — | Held |
| Ishara Investments LP | 12K | $348.5K | — | Held |
| State of Wyoming | 11.3K | $328.6K | — | Held |
| Mutual Advisors, LLC | 10.8K | $314.4K | — | Held |
| CAPTRUST FINANCIAL ADVISORS | 10.7K | $310.1K | — | Held |
| Fiduciary Trust Co | 10.6K | $308.4K | — | Held |
| Ballentine Partners, LLC | 10.6K | $307.4K | — | Held |
| WINTON GROUP Ltd | 10.4K | $302K | — | Held |
| Elo Mutual Pension Insurance Co | 10.4K | $300.9K | — | Held |
| AlphaQuest LLC | 10.2K | $295.5K | — | Held |
| SYON CAPITAL LLC | 10K | $290.6K | — | Held |
| Kestra Advisory Services, LLC | 9.45K | $274.3K | — | Held |
| XPONANCE LLC | 9.4K | $272.9K | — | Held |
| Man Group plc | 8.96K | $260.2K | — | Held |
| Ameritas Investment Partners, Inc. | 8.95K | $259.9K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 8.87K | $257.5K | — | Held |
| MERCER GLOBAL ADVISORS INC /ADV | 8.79K | $255.1K | — | Held |
| CAXTON ASSOCIATES LLP | 8.72K | $253.2K | — | Held |
| CIBC Private Wealth Group LLC | 8.43K | $244.9K | — | Held |
| Brooklyn Investment Group | 8.38K | $239.4K | — | Held |
| Whalen Wealth Management Inc. | 8.01K | $232.7K | — | Held |
| Verition Fund Management LLC | 7.48K | $217.3K | — | Held |
| CIBC WORLD MARKETS CORP | 7.28K | $211.5K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 7.28K | $211.3K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 5.95K | $172.8K | — | Held |
| OSAIC HOLDINGS, INC. | 5.5K | $159.7K | — | Held |
| C M BIDWELL & ASSOCIATES LTD | 5.33K | $154.9K | — | Held |
| Lion Point Capital, LP | 5.25K | $152.5K | — | Held |
| ROYAL BANK OF CANADA | 4.99K | $145K | — | Held |
| Truvestments Capital LLC | 3.01K | $87.5K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 2.41K | $69.9K | — | Held |
| SIGNATUREFD, LLC | 2.15K | $62.3K | — | Held |
| First Command Advisory Services, Inc. | 2K | $58.1K | — | Held |
| QUADRANT CAPITAL GROUP LLC | 1.55K | $45K | — | Held |
| NewEdge Advisors, LLC | 1.54K | $44.9K | — | Held |
| ASSETMARK, INC | 1.52K | $44.1K | — | Held |
| Arax Advisory Partners | 1.48K | $43K | — | Held |
| EverSource Wealth Advisors, LLC | 1.26K | $36.6K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 1.23K | $35.6K | — | Held |
| Quarry LP | 1.2K | $34.8K | — | Held |
| Global Retirement Partners, LLC | 1.2K | $34.7K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.17M | $33.9K | — | Held |
| SBI Securities Co., Ltd. | 1.09K | $31.6K | — | Held |
| GAMMA Investing LLC | 1.04K | $30.2K | — | Held |
| GW&K Investment Management, LLC | 1.01M | $29.3K | — | Held |
| NVWM, LLC | 1K | $29K | — | Held |
| Quantbot Technologies LP | 997 | $29K | — | Held |
| Triumph Capital Management | 900 | $26.1K | — | New |
| SUMMIT SECURITIES GROUP LLC | 822 | $23.9K | — | Held |
| HUNTINGTON NATIONAL BANK | 813 | $23.6K | — | Held |
| Smartleaf Asset Management LLC | 764 | $21.5K | — | Held |
| Allworth Financial LP | 727 | $21.1K | $5.97K | Added$10.1K |
| Sterling Capital Management LLC | 718 | $20.9K | — | Held |
| Essential Partners LLC | 594 | $17.3K | $4.88K | Added$8.22K |
| Farther Finance Advisors, LLC | 574 | $16.7K | — | Held |
| SJS Investment Consulting Inc. | 529 | $15.4K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 529 | $15.4K | — | Held |
| MCGUIRE CAPITAL ADVISORS INC | 510 | $14.8K | — | Held |
| CoreCap Advisors, LLC | 500 | $14.5K | — | Held |
| Optiver Holding B.V. | 393 | $11.4K | — | Held |
| BLUE BELL PRIVATE WEALTH MANAGEMENT, LLC | 369 | $10.7K | — | Held |
| TD Waterhouse Canada Inc. | 318 | $9.23K | — | Held |
| IFP Advisors, Inc | 301 | $8.74K | $1.95K | Added$5.14K |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 300 | $8.71K | — | Held |
| Rachor Investment Advisory Services, LLC | 275 | $7.99K | — | Held |
| Evelyn Partners Investment Management LLP | 270 | $7.84K | $3.62K | Added$3.62K |
| US BANCORP \DE\ | 261 | $7.58K | — | Held |
| Kemnay Advisory Services Inc. | 222 | $6.45K | — | Held |
| Larson Financial Group LLC | 217 | $6.3K | — | Held |
| Prestige Wealth Management Group LLC | 190 | $5.52K | — | New |
| Sound Income Strategies, LLC | 186 | $4.81K | — | Held |
| HM PAYSON & CO | 135 | $3.92K | — | Held |
| Parkside Financial Bank & Trust | 119 | $3.46K | — | Held |
| Steward Partners Investment Advisory, LLC | 113 | $3.28K | — | Held |