| Vivo Capital, LLC | 3.15M | $10.8M | — | New |
| Commodore Capital LP | 2.33M | $7.98M | — | New |
| MILLENNIUM MANAGEMENT LLC | 2.22M | $7.6M | $218.2K | Added$7.49M |
| Spruce Street Capital LP | 1.66M | $5.58M | — | New |
| Almitas Capital LLC | 1.48M | $5.06M | $3.37M | Added$3.37M |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.01M | $3.46M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1M | $3.42M | — | New |
| Woodline Partners LP | 993.7K | $3.4M | $332.8K | Added$3.23M |
| Boxer Capital Management, LLC | 749K | $2.56M | — | New |
| Stonepine Capital Management, LLC | 713.8K | $2.44M | $1.43M | Added$1.73M |
| AMERIPRISE FINANCIAL INC | 696.2K | $2.38M | — | New |
| Sio Capital Management, LLC | 657.2K | $2.25M | — | New |
| Ally Bridge Group (NY) LLC | 526.3K | $1.8M | — | New |
| Prosight Management, LP | 515.8K | $1.76M | — | New |
| BANK OF NOVA SCOTIA | 459.2K | $1.57M | $1.05M | Added$1.05M |
| BANK OF AMERICA CORP /DE/ | 393.7K | $1.35M | $878.5K | Added$907.2K |
| BlackRock, Inc. | 318.8K | $1.09M | $726.8K | Added$721.6K |
| JANE STREET GROUP, LLC | 303.6K | $1.04M | $40.9K | Added$1.02M |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 298.2K | $1.02M | $679.8K | Added$527.5K |
| GEODE CAPITAL MANAGEMENT, LLC | 286.5K | $980.8K | $575K | Added$693.6K |
| BANK OF MONTREAL /CAN/ | 260.1K | $889.6K | $593.1K | Added$408.5K |
| MORGAN STANLEY | 234.2K | $800.9K | $523.9K | Added$539K |
| CANTOR FITZGERALD, L. P. | 200K | $684K | — | New |
| Seven Fleet Capital Management LP | 199.7K | $683K | — | New |
| Renaissance Technologies | 198.8K | $679.9K | $453.3K | Added$293.9K |
| Citadel | 155.2K | $530.9K | $263.4K | Added$399.2K |
| VANGUARD FIDUCIARY TRUST CO | 137.7K | $471K | — | Held |
| State Street | 115.2K | $394K | $198.4K | Added$294.8K |
| Centiva Capital, LP | 75K | $256.5K | — | New |
| UBS Group AG | 61.4K | $210K | $129.2K | Added$145.4K |
| Peapod Lane Capital LLC | 59.9K | $206.9K | $138.7K | Cut−$469.6K |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 59.9K | $204.9K | $136.6K | Added$136.6K |
| NORTHERN TRUST CORP | 43.2K | $147.7K | $98.5K | Added$98.5K |
| CAPTRUST FINANCIAL ADVISORS | 40K | $136.8K | $91.2K | Added$91.2K |
| Persistent Asset Partners Ltd | 38.2K | $130.5K | — | New |
| Hudson Bay Capital Management LP | 34.6K | $118.3K | — | New |
| BNP PARIBAS FINANCIAL MARKETS | 30.1K | $102.9K | $691 | Added$102.5K |
| Qube Research & Technologies Ltd | 24.2K | $82.7K | $23.2K | Added$71K |
| XTX Topco Ltd | 22.4K | $76.6K | — | New |
| CITIGROUP INC | 19.1K | $65.3K | — | New |
| MARSHALL WACE, LLP | 17.7K | $60.5K | — | New |
| OMERS ADMINISTRATION Corp | 15.8K | $54K | — | New |
| ADAR1 Capital Management, LLC | 13.9K | $47.4K | — | New |
| Private Advisor Group, LLC | 12.5K | $42.8K | $28.5K | Added$17.1K |
| FEDERATED HERMES, INC. | 8.32K | $28.5K | $19K | Added$15.4K |
| Vanguard Global Advisers, LLC | 7.33K | $25.1K | — | Held |
| Caitong International Asset Management Co., Ltd | 2.6K | $8.89K | — | New |
| Tower Research Capital LLC (TRC) | 574 | $1.96K | $1.31K | Cut−$363 |
| BARCLAYS PLC | 400 | $1.37K | — | New |
| OSAIC HOLDINGS, INC. | 300 | $1.03K | $684 | Added$684 |
| SBI Securities Co., Ltd. | 201 | $687 | $456 | Added$459 |
| HRT FINANCIAL LP | 32.9K | $112 | — | New |