| 5AM Venture Management, LLC | 3.95M | $9.24M | $3.91M | Added$3.91M |
| Squadron Capital Management LLC | 3.63M | $8.5M | — | New |
| TWO SIGMA INVESTMENTS, LP | 2.96M | $6.92M | $1.46M | Added$4.93M |
| VANGUARD CAPITAL MANAGEMENT LLC | 2.31M | $5.41M | — | Held |
| Renaissance Technologies | 1.94M | $4.54M | $1.92M | Added$642.2K |
| Citadel | 1.73M | $4.05M | $1.71M | Added$1.4M |
| D. E. Shaw & Co., Inc. | 1.48M | $3.47M | $1.47M | Added$1.23M |
| Opaleye Management Inc. | 1.41M | $3.31M | $1.39M | Added$1.41M |
| Decheng Capital LLC | 1.32M | $3.1M | $1.31M | Added$1.31M |
| MILLENNIUM MANAGEMENT LLC | 1.29M | $3.02M | $666.4K | Added$2.11M |
| BlackRock, Inc. | 1.27M | $2.97M | $1.24M | Added$1.28M |
| Ishara Investments LP | 1.23M | $2.88M | $1.22M | Added$1.1M |
| BANK OF AMERICA CORP /DE/ | 1.13M | $2.65M | $1.12M | Added$803.8K |
| PRIMECAP MANAGEMENT CO/CA/ | 957.4K | $2.24M | $947.8K | Added$947.8K |
| Pfizer Inc | 953.8K | $2M | $715.4K | Added$715.4K |
| Connor, Clark & Lunn Investment Management Ltd. | 792K | $1.85M | $779.2K | Added$790.8K |
| Qube Research & Technologies Ltd | 637.1K | $1.49M | $17.3K | Added$1.47M |
| GEODE CAPITAL MANAGEMENT, LLC | 621K | $1.45M | $583.5K | Added$658.3K |
| Almitas Capital LLC | 610.1K | $1.43M | $604K | Added$604K |
| BARCLAYS PLC | 591.2K | $1.38M | $562.8K | Added$616K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 571.3K | $1.34M | $10.2K | Added$1.32M |
| JANE STREET GROUP, LLC | 490.3K | $1.15M | $468.4K | Added$508.6K |
| BNP PARIBAS FINANCIAL MARKETS | 471.4K | $1.1M | $415.2K | Added$537K |
| GOLDMAN SACHS GROUP INC | 462.7K | $1.08M | $117K | Added$923.1K |
| MARSHALL WACE, LLP | 392.6K | $918.8K | $245.3K | Added$584.3K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 360.6K | $843.8K | — | Held |
| Peapod Lane Capital LLC | 366.9K | $834.6K | $339.3K | Added$228.6K |
| MORGAN STANLEY | 350.2K | $819.5K | $346.7K | Cut−$265.4K |
| XTX Topco Ltd | 322.5K | $754.7K | $319.3K | Cut−$23.9K |
| VANGUARD FIDUCIARY TRUST CO | 304.5K | $712.5K | — | Held |
| Creative Planning | 285K | $666.9K | $257.4K | Added$315.9K |
| Fidelity | 283.9K | $664.4K | $240.9K | Added$335.9K |
| CDC Financial, Inc. | 283.8K | $664K | — | New |
| Anfield Capital Management, LLC | 274.5K | $642.4K | $240.2K | Added$314.9K |
| DIMENSIONAL FUND ADVISORS LP | 272K | $634.3K | $94.5K | Added$504.4K |
| Stonepine Capital Management, LLC | 269.1K | $629.7K | $266.4K | Added$3.7K |
| Woodline Partners LP | 266K | $622.5K | $263.4K | Cut−$93.8K |
| State Street | 249.7K | $584.3K | $247.2K | Added$217.4K |
| SEI INVESTMENTS CO | 191.6K | $448.2K | $165.4K | Added$222.6K |
| UBS Group AG | 155.7K | $364.3K | $154.1K | Cut−$546.4K |
| Quarry LP | 150K | $351K | $130.7K | Added$172.8K |
| ADAR1 Capital Management, LLC | 144.6K | $338.4K | $79.2K | Added$230.4K |
| PANAGORA ASSET MANAGEMENT INC | 139.7K | $326.9K | $85.8K | Added$209.9K |
| Invesco Ltd. | 125.8K | $294.3K | $124.5K | Added$39.7K |
| NORTHERN TRUST CORP | 118.2K | $276.6K | $91.9K | Added$151.2K |
| Hudson Bay Capital Management LP | 117.1K | $274.1K | — | New |
| Seven Fleet Capital Management LP | 110K | $257.4K | — | New |
| BARR E S & CO | 110K | $257.4K | $56.9K | Added$179.8K |
| JPMORGAN CHASE & CO | 113.1K | $242.1K | $89.4K | Cut−$7.67K |
| SIMPLEX TRADING, LLC | 98.6K | $230.6K | — | New |
| Point72 Asset Management, L.P. | 94.9K | $222K | $93.9K | Added$86.6K |
| Graham Capital Management, L.P. | 92.4K | $216.3K | $90K | Added$93.5K |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 78.7K | $207.1K | $66.9K | Cut−$25K |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 77.3K | $180.9K | $76.5K | Added$76.5K |
| CITIGROUP INC | 77.3K | $180.8K | — | New |
| 49 WEALTH MANAGEMENT, LLC | 66.4K | $155.4K | $65.7K | Added$59.6K |
| FEDERATED HERMES, INC. | 65.5K | $153.3K | $34.2K | Added$106.6K |
| COMMONWEALTH EQUITY SERVICES, LLC | 61.4K | $143.7K | $60.8K | Added$60.8K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 51.1K | $119.5K | — | New |
| RBF Capital, LLC | 50K | $117K | $49.5K | Added$9K |
| AMERICAN CENTURY COMPANIES INC | 48.6K | $113.7K | $12.8K | Added$96.3K |
| OMERS ADMINISTRATION Corp | 47.7K | $111.6K | — | New |
| Brevan Howard Capital Management LP | 47.1K | $110.1K | — | New |
| TUDOR INVESTMENT CORP ET AL | 34.8K | $81.5K | $34.5K | Added$34.5K |
| Quadrature Capital Ltd | 33.3K | $78K | $33K | Cut−$107.7K |
| Private Advisor Group, LLC | 31.5K | $73.6K | — | New |
| Squarepoint Ops LLC | 30.7K | $71.8K | $30.4K | Cut−$73.6K |
| Headlands Technologies LLC | 29.9K | $70K | — | New |
| Regency Capital Management Inc.\DE | 29.5K | $69K | $29.2K | Added$29.2K |
| State of Wyoming | 28.5K | $66.6K | — | New |
| Carson Advisory Inc. | 23.3K | $54.5K | $23K | Added$22.8K |
| RAYMOND JAMES FINANCIAL INC | 22.9K | $53.6K | $19.7K | Added$26.7K |
| Icahn Capital | 22.7K | $53.1K | $22.4K | Cut−$9.03K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 22.4K | $52.5K | $22.2K | Cut−$16.4K |
| Vanguard Global Advisers, LLC | 21.7K | $50.8K | — | Held |
| PRUDENTIAL FINANCIAL INC | 20.9K | $48.8K | $20.6K | Added$15.6K |
| Schonfeld Strategic Advisors LLC | 20.6K | $48.2K | — | New |
| PRELUDE CAPITAL MANAGEMENT, LLC | 20.4K | $47.7K | — | New |
| Sivia Capital Partners, LLC | 20K | $46.8K | $19.8K | Added$19.8K |
| Birchview Capital, LP | 17.5K | $41K | $16.8K | Added$18K |
| EVERGREEN CAPITAL MANAGEMENT LLC | 16.9K | $39.6K | $16.7K | Added$16.7K |
| Catalyst Funds Management Pty Ltd | 16.7K | $39.1K | — | New |
| CTC Alternative Strategies, Ltd. | 12.5K | $29.3K | — | New |
| Shay Capital LLC | 10.7K | $24.9K | $10.6K | Added$10.6K |
| Cornerstone Wealth Management, LLC | 10.2K | $23.8K | — | New |
| CWM, LLC | 5.38K | $12.6K | $12.6K | Added$12.6K |
| ACADIAN ASSET MANAGEMENT LLC | 2.85M | $6.66K | $2.82K | Added$2.82K |
| EverSource Wealth Advisors, LLC | 1.7K | $3.98K | $1.63K | Added$1.76K |
| GROUP ONE TRADING LLC | 1.46K | $3.42K | — | New |
| Tower Research Capital LLC (TRC) | 1.13K | $2.65K | — | New |
| Wilmington Savings Fund Society, FSB | 1K | $2.34K | $990 | Added$990 |
| GSA CAPITAL PARTNERS LLP | 620.4K | $1.45K | $614 | Cut−$127 |
| NISA INVESTMENT ADVISORS, LLC | 387 | $906 | $384 | Added$384 |
| Fortitude Family Office, LLC | 209 | $489 | — | New |
| HighMark Wealth Management LLC | 130 | $304 | $129 | Added$129 |
| Silicon Valley Capital Partners | 84 | $197 | — | New |
| HRT FINANCIAL LP | 52.2K | $122 | — | New |
| Optiver Holding B.V. | 44 | $103 | $44 | Added$44 |
| SBI Securities Co., Ltd. | 27 | $63 | $27 | Added$27 |
| Inspire Investing, LLC | 21 | $50 | $16 | Added$28 |
| WELLS FARGO & COMPANY/MN | 1 | $1 | — | New |
| ROYAL BANK OF CANADA | 98 | $0 | −$131 | Cut−$17K |