| BVF INC/IL | 2.59M | $81.3M | $12.4M | Added$12.4M |
| MORGAN STANLEY | 1.7M | $53.4M | $8.14M | Added$7.8M |
| Fidelity | 1.3M | $40.9M | $5.55M | Added$9.98M |
| BlackRock, Inc. | 646.9K | $20.3M | $2.92M | Added$4.03M |
| Woodline Partners LP | 640K | $20.1M | $1.26M | Added$13.1M |
| VANGUARD CAPITAL MANAGEMENT LLC | 549.8K | $17.2M | — | Held |
| Opaleye Management Inc. | 300K | $9.41M | $1.4M | Added$1.63M |
| GEODE CAPITAL MANAGEMENT, LLC | 229.8K | $7.21M | $1.06M | Added$1.32M |
| MILLENNIUM MANAGEMENT LLC | 204.9K | $6.43M | — | New |
| State Street | 193.1K | $6.06M | $836.1K | Added$1.41M |
| DIMENSIONAL FUND ADVISORS LP | 133.4K | $4.18M | $207.2K | Added$3.03M |
| Citadel | 98.6K | $3.09M | — | New |
| NORTHERN TRUST CORP | 93.5K | $2.93M | $432.1K | Added$529K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 85.8K | $2.69M | — | Held |
| Bank of New York Mellon Corp | 75K | $2.35M | $326.9K | Added$533.9K |
| UBS Group AG | 72.5K | $2.28M | $124.5K | Added$1.58M |
| Stonepine Capital Management, LLC | 69.5K | $2.18M | $332.2K | Cut−$877.6K |
| Simcoe Capital LLC | 68.1K | $2.13M | — | New |
| VANGUARD FIDUCIARY TRUST CO | 66.7K | $2.09M | — | Held |
| PANAGORA ASSET MANAGEMENT INC | 58.7K | $1.84M | $101.5K | Added$1.28M |
| HighVista Strategies LLC | 46.8K | $1.47M | $223.8K | Cut−$1.53M |
| CM Management, LLC | 40K | $1.25M | $191.2K | Added$191.2K |
| RBF Capital, LLC | 30K | $941.1K | $143.4K | Added$143.4K |
| STATE OF WISCONSIN INVESTMENT BOARD | 28.9K | $906.4K | — | New |
| Quadrature Capital Ltd | 28.5K | $893.9K | — | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 27.2K | $851.7K | $129.8K | Added$70.6K |
| TWO SIGMA INVESTMENTS, LP | 26.1K | $818K | $46.4K | Added$559.7K |
| GOLDMAN SACHS GROUP INC | 24K | $752.8K | $76.9K | Added$324.8K |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 17.6K | $551.5K | $84K | Added$84K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 17.4K | $545.5K | $45.9K | Added$290.4K |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | 17K | $533.3K | $71.7K | Added$134.4K |
| ExodusPoint Capital Management, LP | 14.7K | $460K | — | New |
| JANE STREET GROUP, LLC | 14.5K | $455.5K | — | New |
| Nuveen, LLC | 12.7K | $398.6K | $60.7K | Added$60.7K |
| RHUMBLINE ADVISERS | 11.7K | $367.2K | $55.4K | Added$59.2K |
| BANK OF AMERICA CORP /DE/ | 11K | $345.6K | $52.7K | Added$28.1K |
| DIVERSIFIED MANAGEMENT INC | 10K | $313.7K | $47.8K | Added$47.8K |
| REGIONS FINANCIAL CORP | 9.25K | $290.2K | — | New |
| DEUTSCHE BANK AG\ | 8.45K | $265K | $593 | Added$261.7K |
| Caption Management, LLC | 7.43K | $233.2K | — | New |
| Invesco Ltd. | 6.78K | $212.8K | — | New |
| MetLife Investment Management, LLC | 5.68K | $178.1K | $27.1K | Added$27.1K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4.6K | $144.3K | $21.5K | Added$24.7K |
| Vanguard Global Advisers, LLC | 4.05K | $126.9K | — | Held |
| WELLS FARGO & COMPANY/MN | 3.87K | $121.2K | $18.5K | Cut−$164.7K |
| JPMORGAN CHASE & CO | 3.99K | $120.8K | $14K | Added$18.8K |
| OSAIC HOLDINGS, INC. | 3.44K | $108K | $16.5K | Added$13.8K |
| Police & Firemen's Retirement System of New Jersey | 2.86K | $89.6K | $13.7K | Added$13.7K |
| NEW YORK STATE COMMON RETIREMENT FUND | 2.36K | $74.1K | $11.3K | Added$11.3K |
| BNP PARIBAS FINANCIAL MARKETS | 2.19K | $68.8K | $10.3K | Added$11.6K |
| BARCLAYS PLC | 1.97K | $61.6K | $9.39K | Cut−$332.5K |
| ROYAL BANK OF CANADA | 1K | $31K | $4.4K | Cut−$2K |
| Ameritas Investment Partners, Inc. | 959 | $30.1K | $4.58K | Added$4.58K |
| Legal & General Group Plc | 854 | $26.8K | $4.08K | Added$838 |
| Russell Investments Group, Ltd. | 819 | $25.7K | $3.72K | Added$5K |
| CITIGROUP INC | 753 | $23.6K | $2.65K | Added$8.86K |
| Costello Asset Management, INC | 600 | $18.8K | $2.87K | Added$2.87K |
| Tower Research Capital LLC (TRC) | 572 | $17.9K | $2.24K | Added$5.47K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 514 | $16.1K | $2.46K | Added$569 |
| NATIXIS | 372 | $11.7K | $1.78K | Added$1.78K |
| Truvestments Capital LLC | 290 | $9.1K | $1.39K | Added$1.39K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 283 | $8.88K | — | New |
| GW&K Investment Management, LLC | 232.1K | $7.28K | — | New |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 190 | $5.96K | −$352 | Cut−$636.2K |
| GAMMA Investing LLC | 152 | $4.77K | $540 | Added$1.76K |
| Sterling Capital Management LLC | 145 | $4.55K | $694 | Cut−$1.65K |
| TLS Advisors LLC | 114.9K | $3.6K | −$187 | Added$1.91K |
| CWM, LLC | 113 | $3.54K | $3.54K | Added$3.54K |
| Optiver Holding B.V. | 90 | $2.82K | $315 | Added$1.07K |
| US BANCORP \DE\ | 67 | $2.1K | — | New |
| EverSource Wealth Advisors, LLC | 59 | $1.85K | $281 | Added$15 |
| Ancora Advisors LLC | 31 | $972 | $148 | Added$148 |
| PNC Financial Services Group, Inc. | 25 | $784 | $118 | Added$118 |
| MH & ASSOCIATES SECURITIES MANAGEMENT CORP /ADV | 20 | $628 | $96 | Added$96 |
| NISA INVESTMENT ADVISORS, LLC | 19 | $596 | $91 | Added$91 |
| SBI Securities Co., Ltd. | 14 | $439 | $57 | Added$120 |
| Root Financial Partners, LLC | 13 | $408 | — | New |
| Larson Financial Group LLC | 10 | $314 | — | New |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6.8K | $214 | — | New |
| True Wealth Design, LLC | 4 | $126 | $14 | Added$46 |
| Allworth Financial LP | 3 | $95 | $15 | Cut−$171 |
| ROTHSCHILD INVESTMENT LLC | 3 | $94 | $14 | Added$14 |
| TD Waterhouse Canada Inc. | 1 | $33 | $6 | Added$6 |
| MAI Capital Management | 1 | $32 | — | New |
| State of Alaska, Department of Revenue | 1.05K | $32 | $5 | Added$5 |