| ORBIMED ADVISORS LLC | 2.25M | $14.5M | $6.98M | Added$6.98M |
| Atlas Venture Life Science Advisors, LLC | 2.09M | $13.4M | $6.49M | Added$6.49M |
| Opaleye Management Inc. | 1.26M | $8.06M | $661.4K | Added$7.36M |
| Carlyle Group Inc. | 1.1M | $7.08M | $3.46M | Added$3.46M |
| ARCH Venture Management, LLC | 320.5K | $2.06M | $993.5K | Added$993.5K |
| ACORN CAPITAL ADVISORS, LLC | 315.1K | $2.02M | $976.7K | Added$384.5K |
| VANGUARD CAPITAL MANAGEMENT LLC | 306.4K | $1.97M | — | Held |
| MACKENZIE FINANCIAL CORP | 246.3K | $1.58M | — | New |
| Sanofi | 244.1K | $1.57M | $756.7K | Added$756.7K |
| Renaissance Technologies | 206.9K | $1.33M | $308.8K | Added$997.7K |
| MONIMUS CAPITAL MANAGEMENT, LP | 134.3K | $862.3K | — | New |
| GEODE CAPITAL MANAGEMENT, LLC | 118.2K | $758.7K | $329K | Added$406.3K |
| Pfizer Inc | 101.6K | $736.7K | $399.4K | Cut−$185.5K |
| BlackRock, Inc. | 86.1K | $553.1K | $185.8K | Added$354.1K |
| JANE STREET GROUP, LLC | 65.6K | $421.1K | $78.7K | Added$336.9K |
| MARSHALL WACE, LLP | 52.4K | $336.7K | — | New |
| VANGUARD FIDUCIARY TRUST CO | 50K | $321K | — | Held |
| TWO SIGMA INVESTMENTS, LP | 42.3K | $271.9K | $131.3K | Added$116.4K |
| State Street | 41.5K | $266.5K | $65.8K | Added$196K |
| ADAR1 Capital Management, LLC | 35K | $224.7K | $62K | Added$158.3K |
| Affinity Asset Advisors, LLC | 27.8K | $178.3K | $86.1K | Added$86.1K |
| NORTHERN TRUST CORP | 25K | $160.7K | $77.6K | Added$77.6K |
| Cetera Investment Advisers | 20.7K | $132.9K | — | New |
| AMERICAN CENTURY COMPANIES INC | 18.8K | $120.5K | — | New |
| Citadel | 15.5K | $99.4K | $48K | Cut−$52.4K |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 12.6K | $81K | — | New |
| MORGAN STANLEY | 9.56K | $61.4K | $17K | Added$43.2K |
| EverSource Wealth Advisors, LLC | 4.64K | $29.8K | $14.4K | Added$14.4K |
| Fidelity | 3.4K | $21.8K | $10.4K | Added$10.7K |
| ROYAL BANK OF CANADA | 2.74K | $18K | $542 | Added$17K |
| FEDERATED HERMES, INC. | 2.27K | $14.6K | $7.05K | Added$7.05K |
| Vanguard Global Advisers, LLC | 1.92K | $12.3K | — | Held |
| Tower Research Capital LLC (TRC) | 1.87K | $12K | $3.03K | Added$8.77K |
| Arax Advisory Partners | 1.15K | $7.37K | $3.44K | Added$3.68K |
| Rockefeller Capital Management L.P. | 577 | $3.7K | $1.79K | Added$1.79K |
| JONES FINANCIAL COMPANIES LLLP | 500 | $3.63K | $1.97K | Added$1.97K |
| Russell Investments Group, Ltd. | 454 | $2.92K | $1.41K | Added$1.41K |
| BNP PARIBAS FINANCIAL MARKETS | 303 | $1.95K | $939 | Added$922 |
| UBS Group AG | 270 | $1.73K | $837 | Cut−$43.4K |
| ACADIAN ASSET MANAGEMENT LLC | 172.6K | $1.11K | $151 | Added$947 |
| NISA INVESTMENT ADVISORS, LLC | 166 | $1.07K | $515 | Added$515 |
| OSAIC HOLDINGS, INC. | 124 | $796 | $385 | Added$359 |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 111 | $713 | $93 | Added$613 |
| SBI Securities Co., Ltd. | 104 | $668 | $323 | Added$147 |
| Allworth Financial LP | 98 | $630 | $304 | Added$304 |
| WELLS FARGO & COMPANY/MN | 84 | $539 | — | New |
| Federation des caisses Desjardins du Quebec | 70 | $446 | $215 | Added$215 |
| CWM, LLC | 39 | $250 | $250 | Added$250 |
| Cambridge Investment Research Advisors, Inc. | 35K | $225 | — | New |
| GROUP ONE TRADING LLC | 34 | $218 | $105 | Added$105 |
| HARBOUR INVESTMENTS, INC. | 11 | $71 | $34 | Added$34 |
| AdvisorNet Financial, Inc | 2 | $13 | $6 | Added$6 |
| DANSKE BANK A/S | 1 | $6 | $3 | Added$3 |