| SAMSARA BIOCAPITAL, LLC | 5.19M | $28.8M | $4.68M | Added$4.68M |
| Caligan Partners LP | 4.97M | $27.6M | $1.8M | Added$18.3M |
| Paradigm Biocapital Advisors LP | 4M | $22.2M | $3.6M | Added$3.6M |
| MILLENNIUM MANAGEMENT LLC | 2.99M | $16.6M | $2.39M | Added$4.25M |
| Trails Edge Capital Partners, LP | 2.66M | $14.8M | $2.39M | Added$2.39M |
| FRANKLIN RESOURCES INC | 2.46M | $13.7M | $2.22M | Added$2.04M |
| SymBiosis Capital Partners, LLC | 2.35M | $13.1M | $2.12M | Added$974.7K |
| UBS Group AG | 2.32M | $12.9M | $2.09M | Added$575.5K |
| ADAR1 Capital Management, LLC | 2.17M | $12.1M | $1.96M | Cut−$532.9K |
| Polar Capital Holdings Plc | 2.13M | $11.8M | $1.8M | Added$2.54M |
| ANDERA PARTNERS | 1.82M | $10.1M | $1.64M | Added$1.64M |
| Yu Fan | 1.5M | $8.32M | $1.35M | Added$1.35M |
| BOOTHBAY FUND MANAGEMENT, LLC | 1.47M | $8.16M | $593.1K | Added$5.1M |
| NEA Management Company, LLC | 1.46M | $8.03M | $1.23M | Added$1.23M |
| Ikarian Capital, LLC | 1.43M | $7.84M | $429.4K | Added$5.51M |
| NEXTBio Capital Management LP | 1.33M | $7.4M | $1.17M | Added$1.36M |
| RTW INVESTMENTS, LP | 1.3M | $7.21M | $1.17M | Added$1.17M |
| Deep Track Capital, LP | 1.22M | $6.78M | $441K | Added$4.51M |
| Point72 Asset Management, L.P. | 956.2K | $5.31M | — | New |
| AMERIPRISE FINANCIAL INC | 844.2K | $4.69M | $553.9K | Added$1.82M |
| Ally Bridge Group (NY) LLC | 745.3K | $4.14M | $670.8K | Cut−$2.84M |
| Propel Bio Management, LLC | 724.7K | $3.99M | $624.9K | Cut−$655.4K |
| BVF INC/IL | 686K | $3.81M | $617.4K | Added$617.4K |
| MARSHALL WACE, LLP | 654.2K | $3.63M | $154.9K | Added$2.83M |
| HighVista Strategies LLC | 615.7K | $3.42M | — | New |
| MORGAN STANLEY | 613.4K | $3.4M | $456.9K | Added$1.04M |
| Squadron Capital Management LLC | 535K | $2.97M | $270K | Added$1.57M |
| Integral Health Asset Management, LLC | 400K | $2.22M | — | New |
| DIADEMA PARTNERS LP | 352.4K | $1.94M | $281.1K | Added$380.8K |
| Artisan Partners Limited Partnership | 323K | $1.79M | — | New |
| Simplify Asset Management Inc. | 227.9K | $1.26M | $205.1K | Cut−$305.2K |
| TWO SIGMA INVESTMENTS, LP | 226.4K | $1.26M | $51.7K | Added$989.6K |
| Russell Investments Group, Ltd. | 205.6K | $1.14M | — | New |
| Seven Fleet Capital Management LP | 200.1K | $1.11M | — | New |
| GOLDMAN SACHS GROUP INC | 184.9K | $1.03M | $166.4K | Cut−$971.4K |
| Hudson Bay Capital Management LP | 145.5K | $807.3K | — | New |
| Persistent Asset Partners Ltd | 128.1K | $711K | $115.3K | Added$107.8K |
| J. Goldman & Co LP | 103.5K | $574.5K | $93.2K | Cut−$1.83M |
| Quadrature Capital Ltd | 84.3K | $468K | $60.2K | Added$156.8K |
| COMMONWEALTH EQUITY SERVICES, LLC | 77.6K | $430.5K | $69.8K | Added$69.8K |
| JANE STREET GROUP, LLC | 69.4K | $385.4K | — | New |
| XTX Topco Ltd | 66.1K | $367K | $16.2K | Added$283K |
| Citadel | 65K | $360.5K | $13.2K | Added$292.1K |
| PRELUDE CAPITAL MANAGEMENT, LLC | 40K | $222K | — | New |
| ExodusPoint Capital Management, LP | 38.3K | $212.3K | — | New |
| GEODE CAPITAL MANAGEMENT, LLC | 31.5K | $174.7K | — | New |
| Engineers Gate Manager LP | 27.8K | $154.5K | — | New |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 26.7K | $146K | $24K | Added$29K |
| Quaker Wealth Management, LLC | 25K | $138.5K | — | New |
| NEW YORK STATE COMMON RETIREMENT FUND | 24.5K | $135.8K | — | New |
| Cerity Partners LLC | 20K | $111K | $18K | Added$18K |
| China Universal Asset Management Co., Ltd. | 16K | $88.8K | — | New |
| Frec Markets, Inc. | 10K | $55.5K | — | New |
| BLAIR WILLIAM & CO/IL | 10K | $55.5K | — | New |
| GAMMA Investing LLC | 4.51K | $25.1K | $1.6K | Added$16.8K |
| NewEdge Advisors, LLC | 20K | $20K | −$73K | Cut−$73K |
| RHUMBLINE ADVISERS | 2.86K | $15.9K | $2.37K | Added$3.65K |
| JONES FINANCIAL COMPANIES LLLP | 881 | $5.04K | — | New |
| EverSource Wealth Advisors, LLC | 604 | $3.35K | — | New |
| Atlantic Union Bankshares Corp | 300 | $1.67K | $270 | Added$270 |
| Bell Investment Advisors, Inc | 76 | $422 | — | New |
| HRT FINANCIAL LP | 18.9K | $104 | — | New |
| Virtu Financial LLC | 18.7K | $104 | $11 | Added$44 |
| Western Wealth Management, LLC | 5 | $28 | — | New |
| Caitong International Asset Management Co., Ltd | 2 | $11 | — | New |
| Covestor Ltd | 402 | $2 | $0 | Held |