| Matrix Capital Management Company, LP | 6.92M | $46.3M | $8.58M | Added$8.58M |
| Frazier Life Sciences Management, L.P. | 5.1M | $34.1M | $6.32M | Added$6.32M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4.88M | $32.7M | $6.05M | Added$6.05M |
| Long Focus Capital Management, LLC | 4.62M | $30.9M | $5.73M | Added$5.73M |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4.37M | $29.3M | $5.42M | Added$5.42M |
| BlackRock, Inc. | 3.59M | $24M | $4.41M | Added$4.59M |
| Medicxi Ventures Management (Jersey) Ltd | 3.04M | $20.3M | $3.77M | Added$3.77M |
| VANGUARD CAPITAL MANAGEMENT LLC | 2.24M | $15M | — | Held |
| Nantahala Capital Management, LLC | 2.12M | $14.2M | $2.63M | Added$2.63M |
| FRANKLIN RESOURCES INC | 2.07M | $13.9M | $2.57M | Added$1.89M |
| GEODE CAPITAL MANAGEMENT, LLC | 1.31M | $8.77M | $1.55M | Added$1.92M |
| MILLENNIUM MANAGEMENT LLC | 1.1M | $7.34M | $765.5K | Added$3.98M |
| State Street | 964.7K | $6.45M | $1.15M | Added$1.4M |
| LEVIN CAPITAL STRATEGIES, L.P. | 941.4K | $6.3M | $1.17M | Added$654K |
| B Group, Inc. | 597.6K | $4M | $710K | Added$877.2K |
| ACORN CAPITAL ADVISORS, LLC | 595.7K | $3.99M | $738.7K | Added$738.7K |
| DIMENSIONAL FUND ADVISORS LP | 558.2K | $3.73M | $640K | Added$909K |
| Balyasny Asset Management L.P. | 557.7K | $3.73M | — | New |
| Regency Capital Management Inc.\DE | 532.5K | $3.56M | $660.3K | Added$627.1K |
| NORTHERN TRUST CORP | 430.5K | $2.88M | $511.9K | Added$630.4K |
| VANGUARD FIDUCIARY TRUST CO | 397.2K | $2.66M | — | Held |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 391.3K | $2.62M | — | Held |
| Caligan Partners LP | 229.9K | $1.54M | — | New |
| MORGAN STANLEY | 224K | $1.5M | $270.8K | Added$308.5K |
| GOLDMAN SACHS GROUP INC | 178.7K | $1.2M | $173.5K | Added$433.1K |
| WELLINGTON MANAGEMENT GROUP LLP | 127.5K | $853.3K | $158.2K | Added$85K |
| BANK OF AMERICA CORP /DE/ | 125.4K | $838.6K | $155.4K | Cut−$61.6K |
| UBS Group AG | 118.9K | $795.5K | $147.4K | Cut−$140K |
| PLATINUM INVESTMENT MANAGEMENT LTD | 111.9K | $748.4K | $138.7K | Added$138.7K |
| Renaissance Technologies | 102.1K | $683K | $126.6K | Cut−$108.3K |
| Bank of New York Mellon Corp | 99.4K | $665.2K | $123.3K | Added$77K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 97.1K | $649.9K | $120.5K | Cut−$86.2K |
| Quantinno Capital Management LP | 91.1K | $609.3K | $45.1K | Added$411K |
| BNP PARIBAS FINANCIAL MARKETS | 90.1K | $602.5K | $111.7K | Cut−$22.2K |
| XTX Topco Ltd | 89.5K | $598.9K | $75.4K | Added$267.5K |
| Fisher Asset Management, LLC | 83.5K | $558.7K | — | New |
| Nuveen, LLC | 72.7K | $486.4K | $89.7K | Added$92.2K |
| Permanent Capital Management, LP | 62.4K | $439.7K | $99.8K | Added$26.2K |
| RHUMBLINE ADVISERS | 64.7K | $433K | $80.2K | Added$78.5K |
| TBH Global Asset Management, LLC | 60.3K | $403.6K | $74.8K | Added$74.8K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 57.4K | $384.1K | $69.5K | Added$59.5K |
| Maven Securities LTD | 50K | $334.5K | — | New |
| AMERICAN CENTURY COMPANIES INC | 48.3K | $323.3K | $50.5K | Added$101.2K |
| Icahn Capital | 46.1K | $308.7K | $17.2K | Added$233.1K |
| AMERIPRISE FINANCIAL INC | 42.3K | $282.8K | $52.4K | Added$49.3K |
| TD Asset Management Inc | 40.5K | $271K | $50.2K | Added$50.2K |
| Vanguard Global Advisers, LLC | 39.8K | $266.2K | — | Held |
| DEUTSCHE BANK AG\ | 38K | $254K | $38.2K | Added$86K |
| Invesco Ltd. | 34.3K | $229.3K | $33.8K | Added$80.6K |
| ALLIANCEBERNSTEIN L.P. | 41.7K | $227K | $0 | Held |
| COMMONWEALTH EQUITY SERVICES, LLC | 30.3K | $202.6K | $37.5K | Added$37.5K |
| Brevan Howard Capital Management LP | 29.7K | $199K | — | New |
| Susquehanna Portfolio Strategies, LLC | 28.7K | $192.2K | $35.6K | Cut−$4.49K |
| LETKO, BROSSEAU & ASSOCIATES INC | 28.3K | $189.3K | $35.1K | Added$35.1K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 27.5K | $183.9K | — | New |
| CANADA PENSION PLAN INVESTMENT BOARD | 27K | $180.6K | $23.2K | Added$78.7K |
| EntryPoint Capital, LLC | 26.3K | $175.9K | $32.6K | Added$32.6K |
| MetLife Investment Management, LLC | 25K | $167K | $31K | Added$30.6K |
| JPMORGAN CHASE & CO | 23.5K | $145.9K | $17.3K | Added$19.9K |
| Point72 Asset Management, L.P. | 21.7K | $145.2K | $26.9K | Cut−$152.8K |
| 49 WEALTH MANAGEMENT, LLC | 21.7K | $145.2K | $23.5K | Added$41.7K |
| Trexquant Investment LP | 21K | $140.5K | $26K | Cut−$93.9K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20.9K | $139.6K | $25.2K | Added$28.7K |
| BOOTHBAY FUND MANAGEMENT, LLC | 20.4K | $136.5K | — | New |
| ExodusPoint Capital Management, LP | 18K | $120.1K | $22.3K | Cut−$160.1K |
| Inscription Capital, LLC | 17.8K | $119.1K | — | New |
| WELLS FARGO & COMPANY/MN | 17K | $113.7K | $21.1K | Cut−$153.6K |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 16.3K | $108.9K | $20.2K | Added$20.2K |
| INTECH INVESTMENT MANAGEMENT LLC | 15.8K | $105.6K | $19.6K | Cut−$8.84K |
| Vontobel Holding Ltd. | 15K | $100.3K | — | New |
| Creative Planning | 14.1K | $94.1K | $14K | Added$32.6K |
| BROWN ADVISORY INC | 13.4K | $89.6K | $16.6K | Added$16.6K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 13.3K | $88.8K | — | New |
| NEW YORK STATE COMMON RETIREMENT FUND | 13.1K | $87.7K | $16.2K | Added$16.2K |
| PRELUDE CAPITAL MANAGEMENT, LLC | 13K | $87K | $16.1K | Cut−$185.5K |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 12.9K | $84.5K | $16.2K | Added$24K |
| Citadel | 12.5K | $83.6K | $15.5K | Cut−$289.9K |
| CITIGROUP INC | 12.5K | $83.5K | $15.5K | Cut−$106.7K |
| BARCLAYS PLC | 11.5K | $77.2K | $14.3K | Cut−$300.5K |
| Police & Firemen's Retirement System of New Jersey | 11.4K | $76.2K | $14.1K | Added$14.1K |
| China Universal Asset Management Co., Ltd. | 11.3K | $75.4K | $12.8K | Added$19K |
| Quadrature Capital Ltd | 10.7K | $71.4K | — | New |
| SIMPLEX TRADING, LLC | 8.43K | $56.4K | $3.27K | Added$42K |
| Parallel Advisors, LLC | 5.67K | $37.9K | $3.05K | Added$24.5K |
| Ameritas Investment Partners, Inc. | 4.54K | $30.4K | $5.63K | Added$5.63K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 4.52K | $30.2K | $1.98K | Added$21.5K |
| Legal & General Group Plc | 4.1K | $27.4K | $5.08K | Added$3.74K |
| CWM, LLC | 4.02K | $26.9K | $5.42K | Added$26.9K |
| Tower Research Capital LLC (TRC) | 3.91K | $26.2K | $2.42K | Added$15.5K |
| Russell Investments Group, Ltd. | 3.67K | $24.6K | $4.56K | Added$4.22K |
| Mirae Asset Global Investments Co., Ltd. | 3.31K | $22.2K | $3.83K | Added$5.34K |
| Fidelity | 2.89K | $19.4K | $3.59K | Cut−$25K |
| Rockefeller Capital Management L.P. | 2.87K | $19.2K | $203 | Added$18.3K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2.38K | $15.9K | $2.95K | Added$1.17K |
| Smartleaf Asset Management LLC | 1.79K | $11.1K | $1.24K | Added$1.54K |
| Versant Capital Management, Inc | 1.46K | $9.77K | $983 | Added$5.45K |
| GF FUND MANAGEMENT CO. LTD. | 1.42K | $9.47K | $1.55K | Added$2.68K |
| ROYAL BANK OF CANADA | 1.38K | $9K | $1.34K | Cut−$8K |
| Sterling Capital Management LLC | 1.12K | $7.5K | $1.39K | Cut−$2.34K |
| Arax Advisory Partners | 1.02K | $6.84K | $333 | Added$5.37K |
| OSAIC HOLDINGS, INC. | 926 | $6.19K | $1.15K | Added$1.15K |
| GAMMA Investing LLC | 860 | $5.75K | $51 | Added$5.53K |
| Allworth Financial LP | 745 | $4.99K | $140 | Added$4.37K |
| Essential Partners LLC | 547 | $3.66K | — | New |
| SIGNATUREFD, LLC | 522 | $3.49K | $429 | Added$1.61K |
| FIFTH THIRD BANCORP | 488 | $3.27K | — | New |
| PRICE T ROWE ASSOCIATES INC /MD/ | 415.2K | $2.78K | $515 | Added$364 |
| Optiver Holding B.V. | 392 | $2.62K | $485 | Cut−$561 |
| IFP Advisors, Inc | 195 | $1.3K | $242 | Cut−$673 |
| Parkside Financial Bank & Trust | 169 | $1.13K | $210 | Added$188 |
| EverSource Wealth Advisors, LLC | 161 | $1.08K | $199 | Cut−$493 |
| Blue Trust, Inc. | 86 | $575 | $106 | Added$106 |
| PNC Financial Services Group, Inc. | 83 | $555 | $59 | Added$293 |
| US BANCORP \DE\ | 80 | $535 | $99 | Cut−$653 |
| MassMutual Private Wealth & Trust, FSB | 78 | $522 | — | New |
| SBI Securities Co., Ltd. | 34 | $227 | $42 | Cut−$3.23K |
| ROTHSCHILD INVESTMENT LLC | 31 | $207 | $38 | Added$16 |
| MAI Capital Management | 16 | $108 | — | New |
| True Wealth Design, LLC | 14 | $94 | — | New |
| Farther Finance Advisors, LLC | 8 | $54 | $10 | Cut−$458 |
| Root Financial Partners, LLC | 7 | $47 | $9 | Added$9 |
| Advisory Services Network, LLC | 6 | $40 | — | New |
| Inspire Investing, LLC | 5 | $36 | $6 | Added$13 |
| SJS Investment Consulting Inc. | 2 | $14 | — | New |
| Caitong International Asset Management Co., Ltd | 2 | $13 | — | New |
| Covestor Ltd | 10 | $0 | $0 | Held |